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BDBM50077377 CHEMBL301900::[(R)-2-(4'-Chloro-biphenyl-4-sulfonyl)-7-hydroxy-1,2,3,4-tetrahydro-isoquinolin-3-yl]-oxo-acetic acid

SMILES: OC(=O)C(=O)[C@H]1Cc2ccc(O)cc2CN1S(=O)(=O)c1ccc(cc1)-c1ccc(Cl)cc1

InChI Key: InChIKey=LKNQKZXVRWZYQR-OAQYLSRUSA-N

Data: 1 IC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50077377   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Matrix Metalloproteinase-8 (MMP-8)


(Homo sapiens (Human))
BDBM50077377
PNG
(CHEMBL301900 | [(R)-2-(4'-Chloro-biphenyl-4-sulfon...)
Show SMILES OC(=O)C(=O)[C@H]1Cc2ccc(O)cc2CN1S(=O)(=O)c1ccc(cc1)-c1ccc(Cl)cc1
Show InChI InChI=1S/C23H18ClNO6S/c24-18-6-1-14(2-7-18)15-4-9-20(10-5-15)32(30,31)25-13-17-11-19(26)8-3-16(17)12-21(25)22(27)23(28)29/h1-11,21,26H,12-13H2,(H,28,29)/t21-/m1/s1
PDB
MMDB

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Similars

Article
PubMed
n/an/a 20n/an/an/an/an/an/a



Hoechst Marion Roussel Inc

Curated by ChEMBL


Assay Description
Inhibition of human neutrophil collagenase [Matrix Metalloprotease-8, MMP-8]


J Med Chem 42: 1908-20 (1999)


Article DOI: 10.1021/jm980631s
BindingDB Entry DOI: 10.7270/Q2251JV5
More data for this
Ligand-Target Pair