BDBM50077550 1-{4-[3-(3,5-Difluoro-phenyl)-prop-2-ynyloxy]-[1,2,5]thiadiazol-3-yl}-4-aza-tricyclo[2.2.1.0*2,6*]heptane::CHEMBL291872

SMILES Fc1cc(F)cc(c1)C#CCOc1nsnc1C12CN3CC1C2C3

InChI Key InChIKey=RWIBKAGXMHMEFU-UHFFFAOYSA-N

Data  1 IC50  2 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50077550   

TargetMuscarinic acetylcholine receptor M2(Homo sapiens (Human))
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Curated by ChEMBL
LigandPNGBDBM50077550(1-{4-[3-(3,5-Difluoro-phenyl)-prop-2-ynyloxy]-[1,2...)
Affinity DataEC50:  2.69E+3nMAssay Description:Compound was tested for its potency at M-2 receptor by inhibiting forskolin induced c-AMP formation in CHO-M2 cells human M2 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor M2(RAT)
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Curated by ChEMBL
LigandPNGBDBM50077550(1-{4-[3-(3,5-Difluoro-phenyl)-prop-2-ynyloxy]-[1,2...)
Affinity DataIC50:  30nMAssay Description:Inhibition of [3H]- Oxo-M binding at Muscarinic acetylcholine receptor M2 in rat brain membranes.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor M1(Homo sapiens (Human))
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Curated by ChEMBL
LigandPNGBDBM50077550(1-{4-[3-(3,5-Difluoro-phenyl)-prop-2-ynyloxy]-[1,2...)
Affinity DataEC50:  20nMAssay Description:Stimulation of phosphoinositol hydrolysis in the mouse fibroblast cell line A9L-M1 expressing Muscarinic acetylcholine receptor M1.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed