BDBM50078467 6-[(4-Bromo-phenylamino)-methyl]-5-methyl-pyrido[2,3-d]pyrimidine-2,4-diamine::CHEMBL80065

SMILES Cc1c(CNc2ccc(Br)cc2)cnc2nc(N)nc(N)c12

InChI Key InChIKey=XPCJHZXMQUMYFF-UHFFFAOYSA-N

Data  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50078467   

TargetBifunctional dihydrofolate reductase-thymidylate synthase(Toxoplasma gondii)
Duquesne University

Curated by ChEMBL
LigandPNGBDBM50078467(6-[(4-Bromo-phenylamino)-methyl]-5-methyl-pyrido[2...)
Affinity DataIC50:  9.5nMAssay Description:Inhibition of dihydrofolate reductase (DHFR) from Toxoplasma gondii(tg)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Rattus norvegicus (rat))
Duquesne University

Curated by ChEMBL
LigandPNGBDBM50078467(6-[(4-Bromo-phenylamino)-methyl]-5-methyl-pyrido[2...)
Affinity DataIC50:  34.9nMAssay Description:Inhibition of dihydrofolate reductase (DHFR) from rat liver (rl)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Rattus norvegicus (rat))
Duquesne University

Curated by ChEMBL
LigandPNGBDBM50078467(6-[(4-Bromo-phenylamino)-methyl]-5-methyl-pyrido[2...)
Affinity DataIC50:  34.9nMAssay Description:Inhibition of rat liver dihydrofolate reductaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBifunctional dihydrofolate reductase-thymidylate synthase(Toxoplasma gondii)
Duquesne University

Curated by ChEMBL
LigandPNGBDBM50078467(6-[(4-Bromo-phenylamino)-methyl]-5-methyl-pyrido[2...)
Affinity DataIC50:  9.5nMAssay Description:Inhibition of Toxoplasma gondii dihydrofolate reductaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Pneumocystis carinii)
Duquesne University

Curated by ChEMBL
LigandPNGBDBM50078467(6-[(4-Bromo-phenylamino)-methyl]-5-methyl-pyrido[2...)
Affinity DataIC50:  80.8nMAssay Description:Inhibition of Pneumocystis carinii dihydrofolate reductaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Pneumocystis carinii)
Duquesne University

Curated by ChEMBL
LigandPNGBDBM50078467(6-[(4-Bromo-phenylamino)-methyl]-5-methyl-pyrido[2...)
Affinity DataIC50:  80.8nMAssay Description:Inhibition of dihydrofolate reductase (DHFR) from Pneumocystis carinii(pc)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed