BDBM50078850 CHEBI:4778::Embelin
SMILES CCCCCCCCCCCC1=C(O)C(=O)C=C(O)C1=O
InChI Key InChIKey=IRSFLDGTOHBADP-UHFFFAOYSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 21 hits for monomerid = 50078850
Affinity DataKi: 24nMAssay Description:Displacement of [3H]PSB-1584 from recombinant human GPR84 expressed in CHO cell membranes co-expressing beta-arrestin2 measured after 6 hrs by scinti...More data for this Ligand-Target Pair
TargetPolyunsaturated fatty acid 5-lipoxygenase(Homo sapiens (Human))
University Of Naples
Curated by ChEMBL
University Of Naples
Curated by ChEMBL
Affinity DataIC50: 60nMAssay Description:Inhibition of human 5-LOX by cell free assayMore data for this Ligand-Target Pair
TargetPolyunsaturated fatty acid 5-lipoxygenase(Homo sapiens (Human))
University Of Naples
Curated by ChEMBL
University Of Naples
Curated by ChEMBL
Affinity DataIC50: 1.70E+3nMAssay Description:Inhibition of 5-LOX in A23187-stimulated human blood PMNL assessed as reduction in lipoxygenase products formation pre-incubated for 15 mins followed...More data for this Ligand-Target Pair
TargetPolyunsaturated fatty acid 5-lipoxygenase(Homo sapiens (Human))
University Of Naples
Curated by ChEMBL
University Of Naples
Curated by ChEMBL
Affinity DataIC50: 3.50E+3nMAssay Description:Inhibition of 5-LOX in A23187-stimulated human blood PMNL assessed as reduction in lipoxygenase products formation in presence of arachidonic acid pr...More data for this Ligand-Target Pair
TargetMacrophage-expressed gene 1 protein(Homo sapiens (Human))
University Of Naples
Curated by ChEMBL
University Of Naples
Curated by ChEMBL
Affinity DataIC50: 210nMAssay Description:Inhibition of human mPGES1More data for this Ligand-Target Pair
TargetMacrophage-expressed gene 1 protein(Homo sapiens (Human))
University Of Naples
Curated by ChEMBL
University Of Naples
Curated by ChEMBL
Affinity DataIC50: 210nMAssay Description:Inhibition of mPGES1 in IL-1beta stimulated human A549 cell microsomal membranes assessed as reduction in PGE2 synthase activity after 15 mins using ...More data for this Ligand-Target Pair
Affinity DataIC50: 7.20E+3nMAssay Description:Inhibition of full length recombinant FLAG-tagged PCAF (unknown origin) expressed in baculovirus expression system using histone substrate after 10 m...More data for this Ligand-Target Pair
Affinity DataEC50: 1.23E+4nMAssay Description:Agonist activity at human GPR84 assessed as beta-arrestin recruitment by beta-galactosidase complementation assayMore data for this Ligand-Target Pair
Affinity DataIC50: 4.10E+3nMAssay Description:Inhibition of XIAP (unknown origin)More data for this Ligand-Target Pair
Affinity DataEC50: 795nMAssay Description:Agonist activity at Gi coupled human GPR84 expressed in CHO cells assessed as inhibition of forskolin-induced cAMP accumulation after 15 mins in pres...More data for this Ligand-Target Pair
Affinity DataEC50: 421nMAssay Description:Agonist activity at human PK-tagged GPR84 expressed in CHOK1 cells assessed as EA-tagged beta-arrestin recruitment by beta-galactosidase complementat...More data for this Ligand-Target Pair
Affinity DataEC50: 400nMAssay Description:Agonist activity at human GPR84 expressed in CHO cells assessed as beta-arrestin recruitment after 90 mins by beta-galactosidase complementation assa...More data for this Ligand-Target Pair
TargetProstaglandin E synthase(Homo sapiens (Human))
Abdul Wali Khan University Mardan
Curated by ChEMBL
Abdul Wali Khan University Mardan
Curated by ChEMBL
Affinity DataIC50: 200nMAssay Description:Inhibition of mPGES1 in human A549 cell microsomesMore data for this Ligand-Target Pair
Affinity DataEC50: 5.00E+3nMAssay Description:Agonist activity at recombinant human GPR84 expressed in CHO cells assessed as beta-arrestin 2 recruitment by beta-galactosidase based PathHunter ass...More data for this Ligand-Target Pair
Affinity DataEC50: 630nMAssay Description:Agonist activity at recombinant human N-terminal epitope tagged/C-terminal eYFP-fused FLAG-tagged GPR84 expressed in Flp-In TREx 293 cell membranes a...More data for this Ligand-Target Pair
Affinity DataEC50: 200nMAssay Description:Agonist activity at recombinant human N-terminal epitope tagged/C-terminal eYFP-fused FLAG-tagged GPR84 expressed in Flp-In TREx 293 cell membranes a...More data for this Ligand-Target Pair
Affinity DataEC50: 630nMAssay Description:Agonist activity at recombinant human GPR84 expressed in HEK293 cells co-expressing Gqi5 assessed as inhibition of forskolin-induced cAMP accumulatio...More data for this Ligand-Target Pair
Affinity DataEC50: 421nMAssay Description:Agonist activity at recombinant human GPR84 expressed in CHO cells assessed as inhibition of forskolin-induced cAMP accumulation by fluo-4AM dye base...More data for this Ligand-Target Pair
Affinity DataEC50: 89nMAssay Description:Agonist activity at recombinant human HA-tagged GPR84 stably expressed in HEK293 cells assessed as inhibition of forskolin-induced cAMP accumulation ...More data for this Ligand-Target Pair
TargetPolyunsaturated fatty acid 5-lipoxygenase(Homo sapiens (Human))
University Of Naples
Curated by ChEMBL
University Of Naples
Curated by ChEMBL
Affinity DataIC50: 60nMAssay Description:Inhibition of human recombinant 5-LOX expressed in Escherichia coli BL21 incubated for 10 mins in presence of arachidonic acid by RP-HPLC based cell-...More data for this Ligand-Target Pair
TargetPolyunsaturated fatty acid 5-lipoxygenase(Homo sapiens (Human))
University Of Naples
Curated by ChEMBL
University Of Naples
Curated by ChEMBL
Affinity DataIC50: 800nMAssay Description:Inhibition of human 5-LOX by intact cell based assayMore data for this Ligand-Target Pair