BDBM50081420 (7R,9R)-7-(3,5-Bis-trifluoromethyl-benzyl)-9-methyl-5-p-tolyl-8,9,10,11-tetrahydro-7H-1,7,11a-triaza-cycloocta[b]naphthalene-6,12-dione::(7S,9R)-7-(3,5-Bis-trifluoromethyl-benzyl)-9-methyl-5-p-tolyl-8,9,10,11-tetrahydro-7H-1,7,11a-triaza-cycloocta[b]naphthalene-6,12-dione::CHEMBL339486::TAK-637

SMILES C[C@@H]1CCn2c(c(-c3ccc(C)cc3)c3cccnc3c2=O)C(=O)N(Cc2cc(cc(c2)C(F)(F)F)C(F)(F)F)C1

InChI Key InChIKey=LDXQLWNPGRANTO-GOSISDBHSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50081420   

TargetSubstance-P receptor(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50081420((7R,9R)-7-(3,5-Bis-trifluoromethyl-benzyl)-9-methy...)
Affinity DataIC50:  0.450nMAssay Description:Displacement of [125I]BH-SP from human tachykinin NK1 receptor expressed in IM9 cells after 30 mins by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSubstance-P receptor(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50081420((7R,9R)-7-(3,5-Bis-trifluoromethyl-benzyl)-9-methy...)
Affinity DataIC50:  20nMAssay Description:Tachykinin receptor 1 antagonistic activity as ability to inhibit [125I]-BH-SP binding in human IM-9 cells (lymphoblast cells)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed