BDBM50081908 5-(3-Methoxy-benzyl)-pyrimidine-2,4-diamine::CHEMBL18967

SMILES COc1cccc(Cc2cnc(N)nc2N)c1

InChI Key InChIKey=VJSZGADWCZOKOK-UHFFFAOYSA-N

Data  17 KI  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 18 hits for monomerid = 50081908   

TargetDihydrofolate reductase(Homo sapiens (Human))
Cardiff University

Curated by ChEMBL
LigandPNGBDBM50081908(5-(3-Methoxy-benzyl)-pyrimidine-2,4-diamine | CHEM...)
Affinity DataKi:  9.60nMAssay Description:Inhibition of recombinant Dihydrofolate reductase from humans.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Escherichia coli)
TBA

Curated by ChEMBL
LigandPNGBDBM50081908(5-(3-Methoxy-benzyl)-pyrimidine-2,4-diamine | CHEM...)
Affinity DataKi:  117nMAssay Description:Inhibitory activity against dihydrofolate reductase (DHFR) from Escherichia coli (expressed as log 1/Kiapp)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Escherichia coli)
TBA

Curated by ChEMBL
LigandPNGBDBM50081908(5-(3-Methoxy-benzyl)-pyrimidine-2,4-diamine | CHEM...)
Affinity DataKi:  117nMAssay Description:Compound is evaluated for the inhibition of dihydrofolate reductase from Escherichia coliMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Salmonella enterica subsp. enterica serovar Typhi)
Pomona College

Curated by ChEMBL
LigandPNGBDBM50081908(5-(3-Methoxy-benzyl)-pyrimidine-2,4-diamine | CHEM...)
Affinity DataKi:  117nMAssay Description:Inhibitory activity against Escherichia coli dihydrofolate reductaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Escherichia coli)
TBA

Curated by ChEMBL
LigandPNGBDBM50081908(5-(3-Methoxy-benzyl)-pyrimidine-2,4-diamine | CHEM...)
Affinity DataKi:  117nMAssay Description:Apparent inhibitory (log 1/Ki) activity against Escherichia coli dihydrofolate reductaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Escherichia coli)
TBA

Curated by ChEMBL
LigandPNGBDBM50081908(5-(3-Methoxy-benzyl)-pyrimidine-2,4-diamine | CHEM...)
Affinity DataKi:  117nMAssay Description:Inhibition constant against binding of Escherichia coli dihydrofolate reductaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Homo sapiens (Human))
Cardiff University

Curated by ChEMBL
LigandPNGBDBM50081908(5-(3-Methoxy-benzyl)-pyrimidine-2,4-diamine | CHEM...)
Affinity DataKi:  300nMAssay Description:Inhibition of recombinant Dihydrofolate reductase from Leishmania major.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Homo sapiens (Human))
Cardiff University

Curated by ChEMBL
LigandPNGBDBM50081908(5-(3-Methoxy-benzyl)-pyrimidine-2,4-diamine | CHEM...)
Affinity DataKi:  1.00E+3nMAssay Description:Inhibition of recombinant Dihydrofolate reductase from Trypanosoma cruzi.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Lactobacillus casei)
TBA

Curated by ChEMBL
LigandPNGBDBM50081908(5-(3-Methoxy-benzyl)-pyrimidine-2,4-diamine | CHEM...)
Affinity DataKi:  1.18E+3nMAssay Description:Inhibitory activity against dihydrofolate reductase (DHFR) from Lactobacillus casei (expressed as log 1/Kiapp)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Lactobacillus casei)
TBA

Curated by ChEMBL
LigandPNGBDBM50081908(5-(3-Methoxy-benzyl)-pyrimidine-2,4-diamine | CHEM...)
Affinity DataKi:  1.18E+3nMAssay Description:Inhibitory activity against Lactobacillus casei dihydrofolate reductaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Homo sapiens (Human))
Cardiff University

Curated by ChEMBL
LigandPNGBDBM50081908(5-(3-Methoxy-benzyl)-pyrimidine-2,4-diamine | CHEM...)
Affinity DataKi:  2.30E+3nMAssay Description:Inhibition of recombinant Dihydrofolate reductase from humans.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Bos taurus (Cattle))
TBA

Curated by ChEMBL
LigandPNGBDBM50081908(5-(3-Methoxy-benzyl)-pyrimidine-2,4-diamine | CHEM...)
Affinity DataKi:  2.46E+3nMpH: 7.2Assay Description:Inhibitory activity against bovine liver dihydrofolate reductase at pH 7.2.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Bos taurus (Cattle))
TBA

Curated by ChEMBL
LigandPNGBDBM50081908(5-(3-Methoxy-benzyl)-pyrimidine-2,4-diamine | CHEM...)
Affinity DataKi:  2.46E+3nMpH: 7.2Assay Description:Inhibitory activity against bovine liver dihydrofolate reductase at pH 7.2.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Bos taurus (Cattle))
TBA

Curated by ChEMBL
LigandPNGBDBM50081908(5-(3-Methoxy-benzyl)-pyrimidine-2,4-diamine | CHEM...)
Affinity DataKi:  9.55E+3nMAssay Description:Inhibition of dihydrofolate reductase from bovine liverMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Gallus gallus (Chicken))
TBA

Curated by ChEMBL
LigandPNGBDBM50081908(5-(3-Methoxy-benzyl)-pyrimidine-2,4-diamine | CHEM...)
Affinity DataKi:  3.55E+4nMpH: 7.2Assay Description:Inhibition of Wnt2/beta-catenin signaling in human A549 cells assessed as inhibition of cell proliferation after 48 hrs by MTT assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Gallus gallus (Chicken))
TBA

Curated by ChEMBL
LigandPNGBDBM50081908(5-(3-Methoxy-benzyl)-pyrimidine-2,4-diamine | CHEM...)
Affinity DataKi:  3.55E+4nMAssay Description:Inhibitory activity against chicken liver dihydrofolate reductaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Gallus gallus (Chicken))
TBA

Curated by ChEMBL
LigandPNGBDBM50081908(5-(3-Methoxy-benzyl)-pyrimidine-2,4-diamine | CHEM...)
Affinity DataKi:  3.55E+4nMpH: 7.2Assay Description:Inhibitory activity against chicken dihydrofolate reductase at pH 7.2.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Escherichia coli)
TBA

Curated by ChEMBL
LigandPNGBDBM50081908(5-(3-Methoxy-benzyl)-pyrimidine-2,4-diamine | CHEM...)
Affinity DataIC50:  398nMAssay Description:Compound was tested for inhibition of Escherichia coli Dihydrofolate reductase.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed