BDBM50084154 CHEMBL1233897

SMILES Fc1cccc(c1)-c1ccc(cn1)C(=O)NC1CCN(CC(F)(F)F)CC1

InChI Key InChIKey=LPUCBGGXXIUBAZ-UHFFFAOYSA-N

Data  1 IC50  2 Kd  1 EC50

PDB links: 1 PDB ID matches this monomer.

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50084154   

TargetHematopoietic prostaglandin D synthase(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50084154(CHEMBL1233897)
Affinity DataKd:  9.5nMAssay Description:Binding affinity to human HPGDS expressed in Escherichia coli using 1-phenylpyrazole-4-carboxylic acid/6-(3-fluorophenyl)pyridine-3-carboxamide as re...More data for this Ligand-Target Pair
TargetHematopoietic prostaglandin D synthase(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50084154(CHEMBL1233897)
Affinity DataKd:  20nMAssay Description:Binding affinity to human HPGDS expressed in Escherichia coli by isothermal titration calorimetryMore data for this Ligand-Target Pair
TargetHematopoietic prostaglandin D synthase(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50084154(CHEMBL1233897)
Affinity DataEC50:  35nMAssay Description:Inhibition HPGDS in human MEG01 cells assessed as reduction in PGD2 production incubated for 30 mins followed by stimulation with 5 uM ionomycin for ...More data for this Ligand-Target Pair
TargetHematopoietic prostaglandin D synthase(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50084154(CHEMBL1233897)
Affinity DataIC50:  200nMAssay Description:Inhibition human HPGDS expressed in Escherichia coli assessed as reduction in GST enzymatic activity using MCBL and glutathione incubated for 30 mins...More data for this Ligand-Target Pair