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BDBM50085839 CHEMBL170348::[2-Cyano-5-(pyridin-3-ylmethoxy)-phenoxy]-o-tolyl-acetic acid (0.2H2O)

SMILES: Cc1ccccc1C(Oc1cc(OCc2cccnc2)ccc1C#N)C(O)=O

InChI Key: InChIKey=UNPSSUUNLAENBV-UHFFFAOYSA-N

Data: 1 IC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50085839   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
EDNRA


(RAT)
BDBM50085839
PNG
(CHEMBL170348 | [2-Cyano-5-(pyridin-3-ylmethoxy)-ph...)
Show SMILES Cc1ccccc1C(Oc1cc(OCc2cccnc2)ccc1C#N)C(O)=O
Show InChI InChI=1S/C22H18N2O4/c1-15-5-2-3-7-19(15)21(22(25)26)28-20-11-18(9-8-17(20)12-23)27-14-16-6-4-10-24-13-16/h2-11,13,21H,14H2,1H3,(H,25,26)
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PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 30n/an/an/an/an/an/a



Rhône-Poulenc Rorer

Curated by ChEMBL


Assay Description
In vitro ability to antagonise the binding of [125I]-ET-1 to the rat aortic A10 cell membrane endothelin A receptor.


J Med Chem 43: 900-10 (2000)


Article DOI: 10.1021/jm990378b
BindingDB Entry DOI: 10.7270/Q2154G73
More data for this
Ligand-Target Pair