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BDBM50085858 (2-Chloro-phenyl)-[2-cyano-5-(pyridazin-4-ylmethoxy)-phenoxy]-acetic acid::CHEMBL423608

SMILES: OC(=O)C(Oc1cc(OCc2ccnnc2)ccc1C#N)c1ccccc1Cl

InChI Key: InChIKey=OOQCRFOBRIDXEP-UHFFFAOYSA-N

Data: 1 IC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50085858   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
EDNRA


(RAT)
BDBM50085858
PNG
((2-Chloro-phenyl)-[2-cyano-5-(pyridazin-4-ylmethox...)
Show SMILES OC(=O)C(Oc1cc(OCc2ccnnc2)ccc1C#N)c1ccccc1Cl
Show InChI InChI=1S/C20H14ClN3O4/c21-17-4-2-1-3-16(17)19(20(25)26)28-18-9-15(6-5-14(18)10-22)27-12-13-7-8-23-24-11-13/h1-9,11,19H,12H2,(H,25,26)
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PC sid
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Similars

Article
PubMed
n/an/a 44n/an/an/an/an/an/a



Rhône-Poulenc Rorer

Curated by ChEMBL


Assay Description
In vitro ability to antagonise the binding of [125I]-ET-1 to the rat aortic A10 cell membrane endothelin A receptor.


J Med Chem 43: 900-10 (2000)


Article DOI: 10.1021/jm990378b
BindingDB Entry DOI: 10.7270/Q2154G73
More data for this
Ligand-Target Pair