BDBM50086551 4-Methyl-5-(2,2,4-trimethyl-1,2,3,4-tetrahydro-quinolin-6-yl)-thiophene-2-carbonitrile::CHEMBL134260::racemic-4-methyl-5-(2,2,4-trimethyl-1,2,3,4-tetrahydroquinolin-6-yl)thiophene-2-carbonitrile

SMILES CC1CC(C)(C)Nc2ccc(cc12)-c1sc(cc1C)C#N

InChI Key InChIKey=RSVKCRGCARHPAC-UHFFFAOYSA-N

Data  3 KI  6 IC50  2 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 11 hits for monomerid = 50086551   

TargetProgesterone receptor(Homo sapiens (Human))
Ligand Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50086551(4-Methyl-5-(2,2,4-trimethyl-1,2,3,4-tetrahydro-qui...)
Affinity DataKi:  6.20nMAssay Description:Binding affinity against human progesterone receptor (hPR) in a competitive binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProgesterone receptor(Homo sapiens (Human))
Ligand Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50086551(4-Methyl-5-(2,2,4-trimethyl-1,2,3,4-tetrahydro-qui...)
Affinity DataKi:  8.30nMAssay Description:Binding affinity at progesterone receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlucocorticoid receptor(Homo sapiens (Human))
Ligand Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50086551(4-Methyl-5-(2,2,4-trimethyl-1,2,3,4-tetrahydro-qui...)
Affinity DataKi:  43nMAssay Description:Displacement of radiolabeled Dexamethasone from glucocorticoid receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlucocorticoid receptor(Homo sapiens (Human))
Ligand Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50086551(4-Methyl-5-(2,2,4-trimethyl-1,2,3,4-tetrahydro-qui...)
Affinity DataIC50:  113nMAssay Description:Cross-reactivity as binding to human glucocorticoid receptor (hGR)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProgesterone receptor(Homo sapiens (Human))
Ligand Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50086551(4-Methyl-5-(2,2,4-trimethyl-1,2,3,4-tetrahydro-qui...)
Affinity DataEC50:  2.29E+3nMAssay Description:Human progesterone receptor (hPR) agonist activity expressed in CV-1 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAndrogen receptor(Homo sapiens (Human))
Ligand Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50086551(4-Methyl-5-(2,2,4-trimethyl-1,2,3,4-tetrahydro-qui...)
Affinity DataIC50:  45nMAssay Description:Cross-reactivity as binding to human androgen receptor (hAR)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlucocorticoid receptor(Homo sapiens (Human))
Ligand Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50086551(4-Methyl-5-(2,2,4-trimethyl-1,2,3,4-tetrahydro-qui...)
Affinity DataIC50: >1.00E+3nMAssay Description:Activity at glucocorticoid receptor assessed as repression of TNFalpha and IL1 beta-induced E-selectin expressionMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlucocorticoid receptor(Homo sapiens (Human))
Ligand Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50086551(4-Methyl-5-(2,2,4-trimethyl-1,2,3,4-tetrahydro-qui...)
Affinity DataIC50:  73nMAssay Description:Antagonist activity at glucocorticoid receptor assessed as inhibition of dexamethasone-induced glucose response element transcriptional transactivati...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProgesterone receptor(Homo sapiens (Human))
Ligand Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50086551(4-Methyl-5-(2,2,4-trimethyl-1,2,3,4-tetrahydro-qui...)
Affinity DataIC50:  31nMAssay Description:Binding affinity against human progesterone receptor (hPR) in a competitive binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMineralocorticoid receptor(Homo sapiens (Human))
Ligand Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50086551(4-Methyl-5-(2,2,4-trimethyl-1,2,3,4-tetrahydro-qui...)
Affinity DataIC50:  1.00E+3nMAssay Description:Cross-reactivity as binding to human mineralocorticoid receptor (hMR)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlucocorticoid receptor(Homo sapiens (Human))
Ligand Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50086551(4-Methyl-5-(2,2,4-trimethyl-1,2,3,4-tetrahydro-qui...)
Affinity DataEC50: >1.00E+3nMAssay Description:Agonist activity at glucocorticoid receptor assessed as glucose repsponse element transcriptional transactivation by luciferase assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed