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BDBM50088135 CHEMBL3427236

SMILES: C[C@@H](C(=O)NCCc1ccc(cc1)-c1ccc(CCN2CCC[C@H]2C)cc1)C(=O)OC(C)(C)C

InChI Key: InChIKey=DTZZTBXJVWULRN-YADHBBJMSA-N

Data: 1 IC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50088135   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Histamine H3 receptor


(Homo sapiens (Human))
BDBM50088135
PNG
(CHEMBL3427236)
Show SMILES C[C@@H](C(=O)NCCc1ccc(cc1)-c1ccc(CCN2CCC[C@H]2C)cc1)C(=O)OC(C)(C)C
Show InChI InChI=1S/C29H40N2O3/c1-21-7-6-19-31(21)20-17-24-10-14-26(15-11-24)25-12-8-23(9-13-25)16-18-30-27(32)22(2)28(33)34-29(3,4)5/h8-15,21-22H,6-7,16-20H2,1-5H3,(H,30,32)/t21-,22+/m1/s1
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Similars

Article
PubMed
n/an/a 2.10n/an/an/an/an/an/a



Temple University School of Pharmacy

Curated by ChEMBL


Assay Description
Modulation of human histamine H3 receptor expressed in HEK293 cells assessed as change in forskolin-stimulated cAMP level after 1 hr by HTRF assay


ACS Med Chem Lett 6: 235-6 (2015)


Article DOI: 10.1021/acsmedchemlett.5b00002
BindingDB Entry DOI: 10.7270/Q2PN97B5
More data for this
Ligand-Target Pair