BDBM50088139 CHEMBL3427232::US9365511, 9

SMILES COC(=O)CCc1ccc(cc1)-c1ccc(CCN2CCC[C@H]2C)cc1

InChI Key InChIKey=AAZRUJBRNBEHMO-GOSISDBHSA-N

Data  2 IC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50088139   

TargetHistamine H3 receptor(Homo sapiens (Human))
Temple University School of Pharmacy

Curated by ChEMBL
LigandPNGBDBM50088139(CHEMBL3427232 | US9365511, 9)
Show SMILES COC(=O)CCc1ccc(cc1)-c1ccc(CCN2CCC[C@H]2C)cc1
Show InChI InChI=1S/C23H29NO2/c1-18-4-3-16-24(18)17-15-20-7-12-22(13-8-20)21-10-5-19(6-11-21)9-14-23(25)26-2/h5-8,10-13,18H,3-4,9,14-17H2,1-2H3/t18-/m1/s1
Affinity DataIC50: 1.10nMAssay Description:Modulation of human histamine H3 receptor expressed in HEK293 cells assessed as change in forskolin-stimulated cAMP level after 1 hr by HTRF assayMore data for this Ligand-Target Pair
TargetHistamine H3 receptor(Homo sapiens (Human))
Temple University School of Pharmacy

Curated by ChEMBL
LigandPNGBDBM50088139(CHEMBL3427232 | US9365511, 9)
Show SMILES COC(=O)CCc1ccc(cc1)-c1ccc(CCN2CCC[C@H]2C)cc1
Show InChI InChI=1S/C23H29NO2/c1-18-4-3-16-24(18)17-15-20-7-12-22(13-8-20)21-10-5-19(6-11-21)9-14-23(25)26-2/h5-8,10-13,18H,3-4,9,14-17H2,1-2H3/t18-/m1/s1
Affinity DataIC50: 1.10nMAssay Description:Compounds of the present invention were evaluated using the human H3 receptor (H3R) HTRF cAMP assay. In this assay, HEK293 cells expressing the human...More data for this Ligand-Target Pair