BDBM50088174 CHEMBL3427251

SMILES Cc1noc(C)c1[C@@H]1C[C@](C)(N=C(N)S1)c1cc(c(F)cc1F)-c1cncnc1

InChI Key InChIKey=UWUREBMKVJWTPP-PXNSSMCTSA-N

Data  3 IC50

PDB links: 1 PDB ID matches this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50088174   

TargetBeta-secretase 1(Homo sapiens (Human))
Temple University School Of Pharmacy

Curated by ChEMBL
LigandPNGBDBM50088174(CHEMBL3427251)
Affinity DataIC50:  8nMAssay Description:Inhibition of BACE1 in human H4 cells stably transfected with APP751 containing Swedish mutation assessed as reduction in Abeta (1 to 40) and Abeta (...More data for this Ligand-Target Pair
TargetBeta-secretase 1(Homo sapiens (Human))
Temple University School Of Pharmacy

Curated by ChEMBL
LigandPNGBDBM50088174(CHEMBL3427251)
Affinity DataIC50:  8nMAssay Description:Inhibition of BACE1 in human H4 cells transfected with APP751 assessed as reduction in amyloidbeta level incubated for 19 hrsMore data for this Ligand-Target Pair
TargetBeta-secretase 1(Homo sapiens (Human))
Temple University School Of Pharmacy

Curated by ChEMBL
LigandPNGBDBM50088174(CHEMBL3427251)
Affinity DataIC50:  8nMAssay Description:Inhibition of BACE1 in human H4 cells expressing APP751 Swedish mutant assessed as inhibition of amyloid beta 40 or amyloid beta 42 production incuba...More data for this Ligand-Target Pair