BDBM50093351 CHEMBL3585362

SMILES COc1cc(cnc1Cl)N1CCc2nc(NC(=O)NCCc3cn(CC(F)F)cn3)sc2C1

InChI Key InChIKey=MFASFQBUVZVOCJ-UHFFFAOYSA-N

Data  9 KI  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 13 hits for monomerid = 50093351   

TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform(Homo sapiens (Human))
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50093351(CHEMBL3585362)
Affinity DataKi:  0.00300nMAssay Description:Inhibition of PI3Kgamma (unknown origin) using [33P]ATP and PIP2 incubated for 15 mins by liquid scintillation counting methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase JAK2(Homo sapiens (Human))
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50093351(CHEMBL3585362)
Affinity DataKi:  3.20E+3nMAssay Description:Inhibition of JAK2 (unknown origin) using ATP and polyE4Y substrate by radiometric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMast/stem cell growth factor receptor Kit(Homo sapiens (Human))
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50093351(CHEMBL3585362)
Affinity DataKi: >4.00E+3nMAssay Description:Inhibition of c-KIT (unknown origin) using ATP and polyE4Y substrate by radiometric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA-dependent protein kinase catalytic subunit(Homo sapiens (Human))
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50093351(CHEMBL3585362)
Affinity DataKi: >4.00E+3nMAssay Description:Inhibition of DNAPK (unknown origin) using ATP and PPLSQEAFADLWKKK substrate by radiometric peptide assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReceptor-type tyrosine-protein kinase FLT3(Homo sapiens (Human))
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50093351(CHEMBL3585362)
Affinity DataKi: >4.00E+3nMAssay Description:Inhibition of FLT3 (unknown origin) using ATP and polyE4Y substrate by radiometric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlycogen synthase kinase-3 beta(Homo sapiens (Human))
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50093351(CHEMBL3585362)
Affinity DataKi: >4.00E+3nMAssay Description:Inhibition of GSK3beta (unknown origin) using ATP and GSM peptide substrate by radiometric peptide assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHigh affinity nerve growth factor receptor(Homo sapiens (Human))
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50093351(CHEMBL3585362)
Affinity DataKi: >4.00E+3nMAssay Description:Inhibition of TRKA (unknown origin) using ATP and polyE4Y substrate by radiometric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProto-oncogene tyrosine-protein kinase Src(Homo sapiens (Human))
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50093351(CHEMBL3585362)
Affinity DataKi: >4.00E+3nMAssay Description:Inhibition of SRC (unknown origin) using ATP and polyE4Y substrate by radiometric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50093351(CHEMBL3585362)
Affinity DataKi: >4.00E+3nMAssay Description:Inhibition of KDR (unknown origin) using ATP and polyE4Y substrate by radiometric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform(Homo sapiens (Human))
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50093351(CHEMBL3585362)
Affinity DataIC50: >2.00E+4nMAssay Description:Inhibition of PI3Kdelta in human THP1 cells assessed as inhibition of CSF1-stimulated chemotaxis pre-incubated for 1 hr before MCP1 stimulationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform(Homo sapiens (Human))
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50093351(CHEMBL3585362)
Affinity DataIC50: >2.00E+4nMAssay Description:Inhibition of PI3Kbeta in human THP1 cells assessed as inhibition of CSF1-stimulated chemotaxis pre-incubated for 1 hr before MCP1 stimulationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform(Homo sapiens (Human))
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50093351(CHEMBL3585362)
Affinity DataIC50:  185nMAssay Description:Inhibition of PI3Kgamma in human THP1 cells assessed as inhibition of MCP1-stimulated chemotaxis pre-incubated for 1 hr before MCP1 stimulationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform(Homo sapiens (Human))
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50093351(CHEMBL3585362)
Affinity DataIC50: >2.00E+4nMAssay Description:Inhibition of PI3Kalpha in human THP1 cells assessed as inhibition of CSF1-stimulated chemotaxis pre-incubated for 1 hr before MCP1 stimulationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed