BDBM50093592 17-(2-Hydroxyimino-propyl)-10,13-dimethyl-1,2,6,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-cyclopenta[a]phenanthren-3-one::CHEMBL137040

SMILES CC(CC1CCC2C3CCC4=CC(=O)CCC4(C)C3CCC12C)N=O

InChI Key InChIKey=KNTLRRMPVIPDDX-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50093592   

TargetSteroid 17-alpha-hydroxylase/17,20 lyase(Rattus norvegicus (Rat))
University Of The Saarland

Curated by ChEMBL
LigandPNGBDBM50093592(17-(2-Hydroxyimino-propyl)-10,13-dimethyl-1,2,6,7,...)
Affinity DataIC50:  3.60E+3nMAssay Description:Evaluated for the inhibitory activity towards Cytochrome P450 17 rat enzyme using testicular microsome at 25 uM of substrate (progesterone)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target3-oxo-5-alpha-steroid 4-dehydrogenase 2(Homo sapiens (Human))
University Of The Saarland

Curated by ChEMBL
LigandPNGBDBM50093592(17-(2-Hydroxyimino-propyl)-10,13-dimethyl-1,2,6,7,...)
Affinity DataIC50:  470nMAssay Description:Evaluated for the inhibitory activity against human steroid 5-alpha-reductase type 2 from human BPH tissue at 210 nM of testosteroneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSteroid 17-alpha-hydroxylase/17,20 lyase(Homo sapiens (Human))
University Of The Saarland

Curated by ChEMBL
LigandPNGBDBM50093592(17-(2-Hydroxyimino-propyl)-10,13-dimethyl-1,2,6,7,...)
Affinity DataIC50: >2.50E+3nMAssay Description:Evaluated for the inhibitory activity towards Cytochrome P450 17 human enzyme using testicular microsome at 25 uM of substrate (progesterone)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target3-oxo-5-alpha-steroid 4-dehydrogenase 1(Homo sapiens (Human))
University Of The Saarland

Curated by ChEMBL
LigandPNGBDBM50093592(17-(2-Hydroxyimino-propyl)-10,13-dimethyl-1,2,6,7,...)
Affinity DataIC50:  900nMAssay Description:Evaluated for the inhibitory activity against human steroid 5-alpha-reductase type I in human DU-145 cell assay at 5 nM of androstenedioneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed