BDBM50094009 CHEMBL136800::CX-516::Piperidin-1-yl-quinoxalin-6-yl-methanone::US11718589, Compound 74b

SMILES O=C(N1CCCCC1)c1ccc2nccnc2c1

InChI Key InChIKey=ANDGGVOPIJEHOF-UHFFFAOYSA-N

Data  2 IC50  3 EC50

PDB links: 1 PDB ID matches this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50094009   

TargetGlutamate receptor 4(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50094009(CHEMBL136800 | CX-516 | Piperidin-1-yl-quinoxalin-...)
Affinity DataEC50:  1.56E+5nMAssay Description:Inhibition of GluR4 expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate receptor 4(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50094009(CHEMBL136800 | CX-516 | Piperidin-1-yl-quinoxalin-...)
Affinity DataEC50: >1.00E+6nMAssay Description:Inhibition of GluR4 expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target15-hydroxyprostaglandin dehydrogenase [NAD(+)](Human)
Ut Southwestern Medical Center

Curated by ChEMBL
LigandPNGBDBM50094009(CHEMBL136800 | CX-516 | Piperidin-1-yl-quinoxalin-...)
Affinity DataIC50:  100nMAssay Description:Inhibition of 15-PGDH (unknown origin) using NAD as substrate measured for 3.5 minsMore data for this Ligand-Target Pair
In DepthDetails PubMed
Target15-hydroxyprostaglandin dehydrogenase [NAD(+)](Human)
Ut Southwestern Medical Center

Curated by ChEMBL
LigandPNGBDBM50094009(CHEMBL136800 | CX-516 | Piperidin-1-yl-quinoxalin-...)
Affinity DataIC50:  300nMAssay Description:This Example provides data on two groups (Table 1 and Table 2) of structural analogues of identified 15-PGDH inhibitors. Data provided is the IC50 of...More data for this Ligand-Target Pair
In DepthDetails US Patent

TargetGlutamate receptor 4(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50094009(CHEMBL136800 | CX-516 | Piperidin-1-yl-quinoxalin-...)
Affinity DataEC50: >1.00E+6nMAssay Description:Tested for potentiation towards human iGluR4 receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed