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BDBM50096600 CHEMBL464924::N-((2R,3R,4S,5R)-4-Hydroxy-5-hydroxymethyl-2-{6-[(naphthalen-1-ylmethyl)-amino]-purin-9-yl}-tetrahydro-furan-3-yl)-3-methoxy-benzamide::N-((2R,3R,4S,5R)-4-hydroxy-5-(hydroxymethyl)-2-(6-(naphthalen-1-ylmethylamino)-9H-purin-9-yl)tetrahydrofuran-3-yl)-3-methoxybenzamide::N-(4-Hydroxy-5-hydroxymethyl-2-{6-[(naphthalen-1-ylmethyl)-amino]-9H-purin-3-ylmethyl}-tetrahydro-furan-3-yl)-3-methoxy-benzamide

SMILES: COc1cccc(c1)C(=O)N[C@@H]1[C@H](O)[C@@H](CO)O[C@H]1n1cnc2c(NCc3cccc4ccccc34)ncnc12

InChI Key: InChIKey=UMWAFTCCAGNLMN-BYHVZLFPSA-N

Data: 9 IC50

Find this compound or compounds like it in BindingDB:
Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 9 hits for monomerid = 50096600   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Glyceraldehyde-3-phosphate dehydrogenase liver


(Homo sapiens (Human))
BDBM50096600
PNG
(CHEMBL464924 | N-((2R,3R,4S,5R)-4-Hydroxy-5-hydrox...)
Show SMILES COc1cccc(c1)C(=O)N[C@@H]1[C@H](O)[C@@H](CO)O[C@H]1n1cnc2c(NCc3cccc4ccccc34)ncnc12
Show InChI InChI=1S/C29H28N6O5/c1-39-20-10-5-8-18(12-20)28(38)34-23-25(37)22(14-36)40-29(23)35-16-33-24-26(31-15-32-27(24)35)30-13-19-9-4-7-17-6-2-3-11-21(17)19/h2-12,15-16,22-23,25,29,36-37H,13-14H2,1H3,(H,34,38)(H,30,31,32)/t22-,23-,25-,29-/m1/s1
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PubMed
n/an/a 6.00E+3n/an/an/an/an/an/a



University of Washington

Curated by ChEMBL


Assay Description
Inhibitory concentration against Trypanosoma cruzi glyceraldehyde-3-phosphate dehydrogenase (GAPDH)


Bioorg Med Chem Lett 11: 95-8 (2001)


Article DOI: 10.1016/s0960-894x(00)00608-9
BindingDB Entry DOI: 10.7270/Q2F76D3N
More data for this
Ligand-Target Pair
Glyceraldehyde-3-phosphate dehydrogenase liver


(Homo sapiens (Human))
BDBM50096600
PNG
(CHEMBL464924 | N-((2R,3R,4S,5R)-4-Hydroxy-5-hydrox...)
Show SMILES COc1cccc(c1)C(=O)N[C@@H]1[C@H](O)[C@@H](CO)O[C@H]1n1cnc2c(NCc3cccc4ccccc34)ncnc12
Show InChI InChI=1S/C29H28N6O5/c1-39-20-10-5-8-18(12-20)28(38)34-23-25(37)22(14-36)40-29(23)35-16-33-24-26(31-15-32-27(24)35)30-13-19-9-4-7-17-6-2-3-11-21(17)19/h2-12,15-16,22-23,25,29,36-37H,13-14H2,1H3,(H,34,38)(H,30,31,32)/t22-,23-,25-,29-/m1/s1
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n/an/a 1.20E+4n/an/an/an/an/an/a



University of Washington

Curated by ChEMBL


Assay Description
In vitro inhibition of Trypanosoma cruzi GAPDH.


J Med Chem 44: 2080-93 (2001)


Article DOI: 10.1021/jm000472o
BindingDB Entry DOI: 10.7270/Q2086604
More data for this
Ligand-Target Pair
Glyceraldehyde-3-phosphate dehydrogenase liver


(Homo sapiens (Human))
BDBM50096600
PNG
(CHEMBL464924 | N-((2R,3R,4S,5R)-4-Hydroxy-5-hydrox...)
Show SMILES COc1cccc(c1)C(=O)N[C@@H]1[C@H](O)[C@@H](CO)O[C@H]1n1cnc2c(NCc3cccc4ccccc34)ncnc12
Show InChI InChI=1S/C29H28N6O5/c1-39-20-10-5-8-18(12-20)28(38)34-23-25(37)22(14-36)40-29(23)35-16-33-24-26(31-15-32-27(24)35)30-13-19-9-4-7-17-6-2-3-11-21(17)19/h2-12,15-16,22-23,25,29,36-37H,13-14H2,1H3,(H,34,38)(H,30,31,32)/t22-,23-,25-,29-/m1/s1
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n/an/a 2.50E+4n/an/an/an/an/an/a



University of Washington

Curated by ChEMBL


Assay Description
In vitro inhibition of Trypanosoma brucei GAPDH.


J Med Chem 44: 2080-93 (2001)


Article DOI: 10.1021/jm000472o
BindingDB Entry DOI: 10.7270/Q2086604
More data for this
Ligand-Target Pair
Glyceraldehyde-3-phosphate dehydrogenase liver


(Homo sapiens (Human))
BDBM50096600
PNG
(CHEMBL464924 | N-((2R,3R,4S,5R)-4-Hydroxy-5-hydrox...)
Show SMILES COc1cccc(c1)C(=O)N[C@@H]1[C@H](O)[C@@H](CO)O[C@H]1n1cnc2c(NCc3cccc4ccccc34)ncnc12
Show InChI InChI=1S/C29H28N6O5/c1-39-20-10-5-8-18(12-20)28(38)34-23-25(37)22(14-36)40-29(23)35-16-33-24-26(31-15-32-27(24)35)30-13-19-9-4-7-17-6-2-3-11-21(17)19/h2-12,15-16,22-23,25,29,36-37H,13-14H2,1H3,(H,34,38)(H,30,31,32)/t22-,23-,25-,29-/m1/s1
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n/an/a>5.00E+4n/an/an/an/an/an/a



University of Washington

Curated by ChEMBL


Assay Description
In vitro inhibition of rabbit muscle GAPDH.


J Med Chem 44: 2080-93 (2001)


Article DOI: 10.1021/jm000472o
BindingDB Entry DOI: 10.7270/Q2086604
More data for this
Ligand-Target Pair
Glyceraldehyde-3-phosphate dehydrogenase liver


(Homo sapiens (Human))
BDBM50096600
PNG
(CHEMBL464924 | N-((2R,3R,4S,5R)-4-Hydroxy-5-hydrox...)
Show SMILES COc1cccc(c1)C(=O)N[C@@H]1[C@H](O)[C@@H](CO)O[C@H]1n1cnc2c(NCc3cccc4ccccc34)ncnc12
Show InChI InChI=1S/C29H28N6O5/c1-39-20-10-5-8-18(12-20)28(38)34-23-25(37)22(14-36)40-29(23)35-16-33-24-26(31-15-32-27(24)35)30-13-19-9-4-7-17-6-2-3-11-21(17)19/h2-12,15-16,22-23,25,29,36-37H,13-14H2,1H3,(H,34,38)(H,30,31,32)/t22-,23-,25-,29-/m1/s1
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Article
PubMed
n/an/a 2.50E+4n/an/an/an/an/an/a



University of Washington

Curated by ChEMBL


Assay Description
Inhibitory concentration against Trypanosoma brucei glyceraldehyde-3-phosphate dehydrogenase (GAPDH)


Bioorg Med Chem Lett 11: 95-8 (2001)


Article DOI: 10.1016/s0960-894x(00)00608-9
BindingDB Entry DOI: 10.7270/Q2F76D3N
More data for this
Ligand-Target Pair
Glyceraldehyde-3-phosphate dehydrogenase, glycosomal


(Trypanosoma cruzi)
BDBM50096600
PNG
(CHEMBL464924 | N-((2R,3R,4S,5R)-4-Hydroxy-5-hydrox...)
Show SMILES COc1cccc(c1)C(=O)N[C@@H]1[C@H](O)[C@@H](CO)O[C@H]1n1cnc2c(NCc3cccc4ccccc34)ncnc12
Show InChI InChI=1S/C29H28N6O5/c1-39-20-10-5-8-18(12-20)28(38)34-23-25(37)22(14-36)40-29(23)35-16-33-24-26(31-15-32-27(24)35)30-13-19-9-4-7-17-6-2-3-11-21(17)19/h2-12,15-16,22-23,25,29,36-37H,13-14H2,1H3,(H,34,38)(H,30,31,32)/t22-,23-,25-,29-/m1/s1
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Article
PubMed
n/an/a 1.20E+4n/an/an/an/an/an/a



Universidade de S£o Paulo

Curated by ChEMBL


Assay Description
Inhibition of Trypanosoma cruzi recombinant glycosomal GAPDH expressed in Escherichia coli by spectrophotometry


Bioorg Med Chem 17: 2476-82 (2009)


Article DOI: 10.1016/j.bmc.2009.01.079
BindingDB Entry DOI: 10.7270/Q2BC40FV
More data for this
Ligand-Target Pair
Glyceraldehyde-3-phosphate dehydrogenase liver


(Homo sapiens (Human))
BDBM50096600
PNG
(CHEMBL464924 | N-((2R,3R,4S,5R)-4-Hydroxy-5-hydrox...)
Show SMILES COc1cccc(c1)C(=O)N[C@@H]1[C@H](O)[C@@H](CO)O[C@H]1n1cnc2c(NCc3cccc4ccccc34)ncnc12
Show InChI InChI=1S/C29H28N6O5/c1-39-20-10-5-8-18(12-20)28(38)34-23-25(37)22(14-36)40-29(23)35-16-33-24-26(31-15-32-27(24)35)30-13-19-9-4-7-17-6-2-3-11-21(17)19/h2-12,15-16,22-23,25,29,36-37H,13-14H2,1H3,(H,34,38)(H,30,31,32)/t22-,23-,25-,29-/m1/s1
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PubMed
n/an/a 1.20E+4n/an/an/an/an/an/a



University of Washington

Curated by ChEMBL


Assay Description
Inhibitory concentration against Trypanosoma mexicana glyceraldehyde-3-phosphate dehydrogenase (GAPDH)


Bioorg Med Chem Lett 11: 95-8 (2001)


Article DOI: 10.1016/s0960-894x(00)00608-9
BindingDB Entry DOI: 10.7270/Q2F76D3N
More data for this
Ligand-Target Pair
Glyceraldehyde-3-phosphate dehydrogenase liver


(Homo sapiens (Human))
BDBM50096600
PNG
(CHEMBL464924 | N-((2R,3R,4S,5R)-4-Hydroxy-5-hydrox...)
Show SMILES COc1cccc(c1)C(=O)N[C@@H]1[C@H](O)[C@@H](CO)O[C@H]1n1cnc2c(NCc3cccc4ccccc34)ncnc12
Show InChI InChI=1S/C29H28N6O5/c1-39-20-10-5-8-18(12-20)28(38)34-23-25(37)22(14-36)40-29(23)35-16-33-24-26(31-15-32-27(24)35)30-13-19-9-4-7-17-6-2-3-11-21(17)19/h2-12,15-16,22-23,25,29,36-37H,13-14H2,1H3,(H,34,38)(H,30,31,32)/t22-,23-,25-,29-/m1/s1
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Article
PubMed
n/an/a>5.00E+4n/an/an/an/an/an/a



University of Washington

Curated by ChEMBL


Assay Description
Inhibitory concentration against Trypanosoma brucei glyceraldehyde-3-phosphate dehydrogenase (GAPDH)


Bioorg Med Chem Lett 11: 95-8 (2001)


Article DOI: 10.1016/s0960-894x(00)00608-9
BindingDB Entry DOI: 10.7270/Q2F76D3N
More data for this
Ligand-Target Pair
Glyceraldehyde-3-phosphate dehydrogenase cytosolic


(Leishmania mexicana)
BDBM50096600
PNG
(CHEMBL464924 | N-((2R,3R,4S,5R)-4-Hydroxy-5-hydrox...)
Show SMILES COc1cccc(c1)C(=O)N[C@@H]1[C@H](O)[C@@H](CO)O[C@H]1n1cnc2c(NCc3cccc4ccccc34)ncnc12
Show InChI InChI=1S/C29H28N6O5/c1-39-20-10-5-8-18(12-20)28(38)34-23-25(37)22(14-36)40-29(23)35-16-33-24-26(31-15-32-27(24)35)30-13-19-9-4-7-17-6-2-3-11-21(17)19/h2-12,15-16,22-23,25,29,36-37H,13-14H2,1H3,(H,34,38)(H,30,31,32)/t22-,23-,25-,29-/m1/s1
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PubMed
n/an/a 6.00E+3n/an/an/an/an/an/a



University of Washington

Curated by ChEMBL


Assay Description
Inhibitory activity against Leishmania mexicana GAPDH


J Med Chem 44: 2080-93 (2001)


Article DOI: 10.1021/jm000472o
BindingDB Entry DOI: 10.7270/Q2086604
More data for this
Ligand-Target Pair