BDBM50096645 3-(4'-Cyano-biphenyl-4-yloxy)-N-hydroxy-propionamide::3-(4'-cyanobiphenyl-4-yloxy)-N-hydroxypropanamide::3-[(4'-cyanobiphenyl-4-yl)oxy]-N-hydroxypropanamide::CHEMBL38851

SMILES ONC(=O)CCOc1ccc(cc1)-c1ccc(cc1)C#N

InChI Key InChIKey=XZWFHJUEAVOHHG-UHFFFAOYSA-N

Data  9 IC50  2 Kd

PDB links: 1 PDB ID matches this monomer.

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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 11 hits for monomerid = 50096645   

TargetMatrix metalloproteinase-9(Homo sapiens (Human))
Institut De Recherches Servier

Curated by ChEMBL
LigandPNGBDBM50096645(3-(4'-Cyano-biphenyl-4-yloxy)-N-hydroxy-propionami...)
Affinity DataIC50:  655nMAssay Description:Inhibition of Matrix metalloproteinase-9More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInterstitial collagenase(Homo sapiens (Human))
Institut De Recherches Servier

Curated by ChEMBL
LigandPNGBDBM50096645(3-(4'-Cyano-biphenyl-4-yloxy)-N-hydroxy-propionami...)
Affinity DataIC50: >10nMAssay Description:Inhibition of Matrix metalloproteinase-1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target72 kDa type IV collagenase(Homo sapiens (Human))
Institut De Recherches Servier

Curated by ChEMBL
LigandPNGBDBM50096645(3-(4'-Cyano-biphenyl-4-yloxy)-N-hydroxy-propionami...)
Affinity DataIC50:  49nMAssay Description:Inhibition of Matrix metalloproteinase-2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCollagenase 3(Homo sapiens (Human))
Institut De Recherches Servier

Curated by ChEMBL
LigandPNGBDBM50096645(3-(4'-Cyano-biphenyl-4-yloxy)-N-hydroxy-propionami...)
Affinity DataIC50:  64nMAssay Description:Inhibition of Matrix metalloproteinase-13More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetStromelysin-1(Homo sapiens (Human))
Institut De Recherches Servier

Curated by ChEMBL
LigandPNGBDBM50096645(3-(4'-Cyano-biphenyl-4-yloxy)-N-hydroxy-propionami...)
Affinity DataIC50:  47nMAssay Description:Inhibition of Matrix metalloproteinase-3More data for this Ligand-Target Pair
TargetStromelysin-1(Homo sapiens (Human))
Institut De Recherches Servier

Curated by ChEMBL
LigandPNGBDBM50096645(3-(4'-Cyano-biphenyl-4-yloxy)-N-hydroxy-propionami...)
Affinity DataKd:  110nMAssay Description:Binding affinity to stromelysin-1 catalytic domain expressed in Escherichia coli BL21 (DE3) by isothermal titration colorimetryMore data for this Ligand-Target Pair
Target72 kDa type IV collagenase(Homo sapiens (Human))
Institut De Recherches Servier

Curated by ChEMBL
LigandPNGBDBM50096645(3-(4'-Cyano-biphenyl-4-yloxy)-N-hydroxy-propionami...)
Affinity DataIC50:  32nMAssay Description:In vitro inhibition of Matrix metalloproteinase-2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetStromelysin-1(Homo sapiens (Human))
Institut De Recherches Servier

Curated by ChEMBL
LigandPNGBDBM50096645(3-(4'-Cyano-biphenyl-4-yloxy)-N-hydroxy-propionami...)
Affinity DataIC50:  57nMAssay Description:In vitro inhibition of Matrix metalloproteinase-3More data for this Ligand-Target Pair
TargetStromelysin-1(Homo sapiens (Human))
Institut De Recherches Servier

Curated by ChEMBL
LigandPNGBDBM50096645(3-(4'-Cyano-biphenyl-4-yloxy)-N-hydroxy-propionami...)
Affinity DataIC50:  25nMAssay Description:Inhibition of Matrix Metalloprotease-3 (MMP-3)More data for this Ligand-Target Pair
TargetStromelysin-1(Homo sapiens (Human))
Institut De Recherches Servier

Curated by ChEMBL
LigandPNGBDBM50096645(3-(4'-Cyano-biphenyl-4-yloxy)-N-hydroxy-propionami...)
Affinity DataKd:  100nMAssay Description:Binding affinity to stromelysin-1 catalytic domainMore data for this Ligand-Target Pair
TargetInterstitial collagenase(Homo sapiens (Human))
Institut De Recherches Servier

Curated by ChEMBL
LigandPNGBDBM50096645(3-(4'-Cyano-biphenyl-4-yloxy)-N-hydroxy-propionami...)
Affinity DataIC50:  3.30E+3nMAssay Description:In vitro inhibition of Matrix metalloproteinase-1.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed