BDBM50099663 CHEMBL3319482
SMILES C[C@@H](NC(=O)C1=C(C)c2ccccc2C1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](Cc1ccccc1)C(=O)[C@@]1(C)CO1
InChI Key InChIKey=MEEMIPFAQCGZFR-UHFFFAOYSA-N
Data 33 IC50
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 33 hits for monomerid = 50099663
TargetProteasome subunit beta type-8(Homo sapiens (Human))
Leiden Institute Of Chemistry And Netherlands Proteomics Centre
Curated by ChEMBL
Leiden Institute Of Chemistry And Netherlands Proteomics Centre
Curated by ChEMBL
Affinity DataIC50: 2.5nMAssay Description:Inhibition of proteasome subunit beta-5i in human Raji cells using BODIPY-NC005 by fluorescent densitometryMore data for this Ligand-Target Pair
Affinity DataIC50: 2.21E+3nMAssay Description:Inhibition of LMP2 in human MOLT4 cells by ELISAMore data for this Ligand-Target Pair
TargetProteasome subunit beta type-10(Homo sapiens (Human))
Leiden Institute Of Chemistry And Netherlands Proteomics Centre
Curated by ChEMBL
Leiden Institute Of Chemistry And Netherlands Proteomics Centre
Curated by ChEMBL
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of proteasome subunit beta-2i in human Raji cells using BODIPY- epoxomicin by fluorescent densitometryMore data for this Ligand-Target Pair
TargetProteasome subunit beta type-8(Homo sapiens (Human))
Leiden Institute Of Chemistry And Netherlands Proteomics Centre
Curated by ChEMBL
Leiden Institute Of Chemistry And Netherlands Proteomics Centre
Curated by ChEMBL
Affinity DataIC50: 25nMAssay Description:Inhibition of proteasome subunit beta-5i in human RPMI8226 cells using BODIPY-NC005 by fluorescent densitometryMore data for this Ligand-Target Pair
Affinity DataIC50: 3.50E+3nMAssay Description:Inhibition of proteasome subunit beta-1i in human RPMI8226 cells using BODIPY-NC001 by fluorescent densitometryMore data for this Ligand-Target Pair
TargetProteasome subunit beta type-10(Homo sapiens (Human))
Leiden Institute Of Chemistry And Netherlands Proteomics Centre
Curated by ChEMBL
Leiden Institute Of Chemistry And Netherlands Proteomics Centre
Curated by ChEMBL
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of proteasome subunit beta-2i in human RPMI8226 cells using BODIPY-epoxomicin by fluorescent densitometryMore data for this Ligand-Target Pair
TargetProteasome subunit beta type-8(Homo sapiens (Human))
Leiden Institute Of Chemistry And Netherlands Proteomics Centre
Curated by ChEMBL
Leiden Institute Of Chemistry And Netherlands Proteomics Centre
Curated by ChEMBL
Affinity DataIC50: 3.00E+3nMAssay Description:Inhibition of immunoproteasome subunit LMP7 in human OPM1 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assayMore data for this Ligand-Target Pair
TargetProteasome subunit beta type-8(Homo sapiens (Human))
Leiden Institute Of Chemistry And Netherlands Proteomics Centre
Curated by ChEMBL
Leiden Institute Of Chemistry And Netherlands Proteomics Centre
Curated by ChEMBL
Affinity DataIC50: 3.00E+3nMAssay Description:Inhibition of immunoproteasome subunit LMP7 in human MM.1S cells assessed as reduction in cell viability incubated for 48 hrs by MTT assayMore data for this Ligand-Target Pair
TargetProteasome subunit beta type-8(Homo sapiens (Human))
Leiden Institute Of Chemistry And Netherlands Proteomics Centre
Curated by ChEMBL
Leiden Institute Of Chemistry And Netherlands Proteomics Centre
Curated by ChEMBL
Affinity DataIC50: 3.00E+3nMAssay Description:Inhibition of immunoproteasome subunit LMP7 in human RPMI8226 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assayMore data for this Ligand-Target Pair
TargetProteasome subunit beta type-8(Homo sapiens (Human))
Leiden Institute Of Chemistry And Netherlands Proteomics Centre
Curated by ChEMBL
Leiden Institute Of Chemistry And Netherlands Proteomics Centre
Curated by ChEMBL
Affinity DataIC50: 3.00E+3nMAssay Description:Inhibition of immunoproteasome subunit LMP7 in human LR5 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assayMore data for this Ligand-Target Pair
TargetProteasome subunit beta type-8(Homo sapiens (Human))
Leiden Institute Of Chemistry And Netherlands Proteomics Centre
Curated by ChEMBL
Leiden Institute Of Chemistry And Netherlands Proteomics Centre
Curated by ChEMBL
Affinity DataIC50: 3.00E+3nMAssay Description:Inhibition of immunoproteasome subunit LMP7 in human DOX40 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assayMore data for this Ligand-Target Pair
TargetProteasome subunit beta type-8(Homo sapiens (Human))
Leiden Institute Of Chemistry And Netherlands Proteomics Centre
Curated by ChEMBL
Leiden Institute Of Chemistry And Netherlands Proteomics Centre
Curated by ChEMBL
Affinity DataIC50: 3.00E+3nMAssay Description:Inhibition of immunoproteasome subunit LMP7 in human INA60 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assayMore data for this Ligand-Target Pair
TargetProteasome subunit beta type-8(Homo sapiens (Human))
Leiden Institute Of Chemistry And Netherlands Proteomics Centre
Curated by ChEMBL
Leiden Institute Of Chemistry And Netherlands Proteomics Centre
Curated by ChEMBL
Affinity DataIC50: 3.00E+3nMAssay Description:Inhibition of immunoproteasome subunit LMP7 in human MM.1R cells assessed as reduction in cell viability incubated for 48 hrs by MTT assayMore data for this Ligand-Target Pair
TargetProteasome subunit beta type-8(Homo sapiens (Human))
Leiden Institute Of Chemistry And Netherlands Proteomics Centre
Curated by ChEMBL
Leiden Institute Of Chemistry And Netherlands Proteomics Centre
Curated by ChEMBL
Affinity DataIC50: 3.00E+3nMAssay Description:Inhibition of immunoproteasome subunit LMP7 in human KMS12PE cells assessed as reduction in cell viability incubated for 48 hrs by MTT assayMore data for this Ligand-Target Pair
TargetProteasome subunit beta type-8(Homo sapiens (Human))
Leiden Institute Of Chemistry And Netherlands Proteomics Centre
Curated by ChEMBL
Leiden Institute Of Chemistry And Netherlands Proteomics Centre
Curated by ChEMBL
Affinity DataIC50: 3.00E+3nMAssay Description:Inhibition of immunoproteasome subunit OPM2 in human OPM1 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assayMore data for this Ligand-Target Pair
Affinity DataIC50: >2.50E+4nMAssay Description:Inhibition of 20S proteosome beta 2 in human MOLT4 cells by ELISAMore data for this Ligand-Target Pair
Affinity DataIC50: >2.50E+4nMAssay Description:Inhibition of 20S proteosome beta 1 in human MOLT4 cells by ELISAMore data for this Ligand-Target Pair
TargetProteasome subunit beta type-8(Homo sapiens (Human))
Leiden Institute Of Chemistry And Netherlands Proteomics Centre
Curated by ChEMBL
Leiden Institute Of Chemistry And Netherlands Proteomics Centre
Curated by ChEMBL
Affinity DataIC50: 39nMAssay Description:Inhibition of LMP7 in human MOLT4 cells by ELISAMore data for this Ligand-Target Pair
TargetProteasome subunit beta type-10(Homo sapiens (Human))
Leiden Institute Of Chemistry And Netherlands Proteomics Centre
Curated by ChEMBL
Leiden Institute Of Chemistry And Netherlands Proteomics Centre
Curated by ChEMBL
Affinity DataIC50: >2.50E+4nMAssay Description:Inhibition of MECL1 in human MOLT4 cells by ELISAMore data for this Ligand-Target Pair
Affinity DataIC50: >2.50E+4nMAssay Description:Inhibition of 20S proteosome beta 2 in human MOLT4 cells by ELISAMore data for this Ligand-Target Pair
Affinity DataIC50: 1.36E+3nMAssay Description:Inhibition of 20S proteosome beta 5 in mouse A20 cells by ELISAMore data for this Ligand-Target Pair
Affinity DataIC50: 4.78E+3nMAssay Description:Inhibition of LMP2 in mouse A20 cells by ELISAMore data for this Ligand-Target Pair
TargetProteasome subunit beta type-10(Homo sapiens (Human))
Leiden Institute Of Chemistry And Netherlands Proteomics Centre
Curated by ChEMBL
Leiden Institute Of Chemistry And Netherlands Proteomics Centre
Curated by ChEMBL
Affinity DataIC50: >2.50E+4nMAssay Description:Inhibition of MECL1 in human MOLT4 cells by ELISAMore data for this Ligand-Target Pair
TargetProteasome subunit beta type-8(Homo sapiens (Human))
Leiden Institute Of Chemistry And Netherlands Proteomics Centre
Curated by ChEMBL
Leiden Institute Of Chemistry And Netherlands Proteomics Centre
Curated by ChEMBL
Affinity DataIC50: 39nMAssay Description:Inhibition of LMP7 in human MOLT4 cells by ELISAMore data for this Ligand-Target Pair
Affinity DataIC50: 2.21E+3nMAssay Description:Inhibition of LMP2 in human MOLT4 cells by ELISAMore data for this Ligand-Target Pair
Affinity DataIC50: 573nMAssay Description:Inhibition of LMP7 in mouse A20 cells by ELISAMore data for this Ligand-Target Pair
Affinity DataIC50: 573nMAssay Description:Inhibition of LMP7 in mouse A20 cells by ELISAMore data for this Ligand-Target Pair
Affinity DataIC50: 4.78E+3nMAssay Description:Inhibition of LMP2 in mouse A20 cells by ELISAMore data for this Ligand-Target Pair
Affinity DataIC50: >2.50E+4nMAssay Description:Inhibition of 20S proteosome beta 1 in human MOLT4 cells by ELISAMore data for this Ligand-Target Pair
Affinity DataIC50: 1.67E+3nMAssay Description:Inhibition of 20S proteosome beta 5 in human MOLT4 cells by ELISAMore data for this Ligand-Target Pair
Affinity DataIC50: 1.67E+3nMAssay Description:Inhibition of 20S proteosome beta 5 in human MOLT4 cells by ELISAMore data for this Ligand-Target Pair
Affinity DataIC50: 1.36E+3nMAssay Description:Inhibition of 20S proteosome beta 5 in mouse A20 cells by ELISAMore data for this Ligand-Target Pair
Affinity DataIC50: 1.84E+3nMAssay Description:Inhibition of proteasome subunit beta-1i in human Raji cells using BODIPY- epoxomicin by fluorescent densitometryMore data for this Ligand-Target Pair