BDBM50101075 (2S,3S)-3-(3,4-Dichloro-phenyl)-2-methoxycarbonyl-8-methyl-8-azonia-bicyclo[3.2.1]octane::(2S,3S)-3-(3,4-Dichloro-phenyl)-8-methyl-8-aza-bicyclo[3.2.1]octane-2-carboxylic acid methyl ester::(2S,3S)-methyl 3-(3,4-dichlorophenyl)-8-methyl-8-aza-bicyclo[3.2.1]octane-2-carboxylate::3-(3,4-Dichloro-phenyl)-8-methyl-8-aza-bicyclo[3.2.1]octane-2-carboxylic acid methyl ester::CHEMBL42553::RTI-111

SMILES COC(=O)[C@@H]1C2CCC(C[C@@H]1c1ccc(Cl)c(Cl)c1)N2C

InChI Key InChIKey=AMIHUYQKNJHXPT-XNSJETLRSA-N

Data  12 KI  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 16 hits for monomerid = 50101075   

TargetSodium-dependent dopamine transporter(Homo sapiens (Human))
National Institute On Drug Abuse-Intramural Research Program

Curated by ChEMBL
LigandPNGBDBM50101075((2S,3S)-3-(3,4-Dichloro-phenyl)-2-methoxycarbonyl-...)
Affinity DataKi:  0.200nMAssay Description:Displacement of [3H]CFT from human DAT expressed in COS7 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent dopamine transporter(Rattus norvegicus (rat))
Virginia Commonwealth University

Curated by PDSP Ki Database
LigandPNGBDBM50101075((2S,3S)-3-(3,4-Dichloro-phenyl)-2-methoxycarbonyl-...)
Affinity DataKi:  0.790nMMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetSodium-dependent serotonin transporter(Rattus norvegicus (rat))
National Institute On Drug Abuse

Curated by ChEMBL
LigandPNGBDBM50101075((2S,3S)-3-(3,4-Dichloro-phenyl)-2-methoxycarbonyl-...)
Affinity DataKi:  1.46nMAssay Description:Binding affinity towards serotonin transporter using [3H]citalopram as radioligand was determinedMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent dopamine transporter(Homo sapiens (Human))
National Institute On Drug Abuse-Intramural Research Program

Curated by ChEMBL
LigandPNGBDBM50101075((2S,3S)-3-(3,4-Dichloro-phenyl)-2-methoxycarbonyl-...)
Affinity DataKi:  2.30nMAssay Description:Displacement of [3H]dopamine from human DAT expressed in COS7 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Rattus norvegicus (rat))
National Institute On Drug Abuse

Curated by ChEMBL
LigandPNGBDBM50101075((2S,3S)-3-(3,4-Dichloro-phenyl)-2-methoxycarbonyl-...)
Affinity DataKi:  3.10nMMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetSodium-dependent noradrenaline transporter(Homo sapiens (Human))
National Institute On Drug Abuse-Intramural Research Program

Curated by ChEMBL
LigandPNGBDBM50101075((2S,3S)-3-(3,4-Dichloro-phenyl)-2-methoxycarbonyl-...)
Affinity DataKi:  5nMAssay Description:Displacement of [3H]dopamine from human NET expressed in COS7 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent dopamine transporter(Rattus norvegicus (rat))
Virginia Commonwealth University

Curated by PDSP Ki Database
LigandPNGBDBM50101075((2S,3S)-3-(3,4-Dichloro-phenyl)-2-methoxycarbonyl-...)
Affinity DataKi:  6.30nMAssay Description:In vitro dopamine transporter binding affinity using [3H]WIN-35428 as radioligand was determinedMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
National Institute On Drug Abuse-Intramural Research Program

Curated by ChEMBL
LigandPNGBDBM50101075((2S,3S)-3-(3,4-Dichloro-phenyl)-2-methoxycarbonyl-...)
Affinity DataKi:  12nMAssay Description:Displacement of [3H]5HT from human SERT expressed in COS7 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransporter(Rattus norvegicus)
National Institute On Drug Abuse

Curated by ChEMBL
LigandPNGBDBM50101075((2S,3S)-3-(3,4-Dichloro-phenyl)-2-methoxycarbonyl-...)
Affinity DataKi:  15.8nMAssay Description:Binding affinity towards norepinephrine transporter using [3H]nisoxetine as radioligand was determinedMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNorepinephrine transporter(RAT)
Virginia Commonwealth University

Curated by PDSP Ki Database
LigandPNGBDBM50101075((2S,3S)-3-(3,4-Dichloro-phenyl)-2-methoxycarbonyl-...)
Affinity DataKi:  17.9nMMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetSodium-dependent dopamine transporter(Rattus norvegicus (rat))
Virginia Commonwealth University

Curated by PDSP Ki Database
LigandPNGBDBM50101075((2S,3S)-3-(3,4-Dichloro-phenyl)-2-methoxycarbonyl-...)
Affinity DataKi:  100nMAssay Description:Binding affinity towards dopamine transporterMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor M1(RAT)
National Institute On Drug Abuse

Curated by ChEMBL
LigandPNGBDBM50101075((2S,3S)-3-(3,4-Dichloro-phenyl)-2-methoxycarbonyl-...)
Affinity DataKi:  3.14E+3nMAssay Description:Binding affinity towards Muscarinic acetylcholine receptor M1 using [3H]pirenzepine as radioligand was determinedMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent dopamine transporter(Homo sapiens (Human))
National Institute On Drug Abuse-Intramural Research Program

Curated by ChEMBL
LigandPNGBDBM50101075((2S,3S)-3-(3,4-Dichloro-phenyl)-2-methoxycarbonyl-...)
Affinity DataIC50:  1.10nMAssay Description:Ability of the compound to inhibit human dopamine uptake by the human dopamine transporter in EM4 cells stably infected with Flag HA-hDATMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent dopamine transporter(Rattus norvegicus (rat))
Virginia Commonwealth University

Curated by PDSP Ki Database
LigandPNGBDBM50101075((2S,3S)-3-(3,4-Dichloro-phenyl)-2-methoxycarbonyl-...)
Affinity DataIC50:  1.40nMAssay Description:In vitro potency for inhibiting [3H]- dopamine uptake in rat brain was determinedMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
National Institute On Drug Abuse-Intramural Research Program

Curated by ChEMBL
LigandPNGBDBM50101075((2S,3S)-3-(3,4-Dichloro-phenyl)-2-methoxycarbonyl-...)
Affinity DataIC50:  2.5nMAssay Description:Displacement of [3H]-citalopram from human SERT expressed in HEK293 cell membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent dopamine transporter(Homo sapiens (Human))
National Institute On Drug Abuse-Intramural Research Program

Curated by ChEMBL
LigandPNGBDBM50101075((2S,3S)-3-(3,4-Dichloro-phenyl)-2-methoxycarbonyl-...)
Affinity DataIC50:  1.10nMAssay Description:Displacement of [3H]WIN-35428 from human DAT expressed in transfected cell membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed