BDBM50102614 7-Isobutyl-8-oxo-2-oxa-9-aza-bicyclo[11.2.2]heptadeca-1(16),13(17),14-triene-6,10-dicarboxylic acid 6-hydroxyamide 10-methylamide::CHEMBL433381

SMILES CNC(=O)[C@@H]1CCc2ccc(OCCC[C@@H]([C@@H](CC(C)C)C(=O)N1)C(=O)NO)cc2

InChI Key InChIKey=CFUYAVWBVRZFLA-OTWHNJEPSA-N

Data  3 KI  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50102614   

TargetMatrix metalloproteinase-9(Homo sapiens (Human))
Dupont Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50102614(7-Isobutyl-8-oxo-2-oxa-9-aza-bicyclo[11.2.2]heptad...)
Affinity DataKi:  2.10nMAssay Description:In vitro inhibition of human MMP-9.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInterstitial collagenase(Homo sapiens (Human))
Dupont Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50102614(7-Isobutyl-8-oxo-2-oxa-9-aza-bicyclo[11.2.2]heptad...)
Affinity DataKi:  5.30nMAssay Description:In vitro inhibition of human MMP-1.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetStromelysin-1(Homo sapiens (Human))
Dupont Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50102614(7-Isobutyl-8-oxo-2-oxa-9-aza-bicyclo[11.2.2]heptad...)
Affinity DataKi:  48nMAssay Description:Inhibition of human MMP-3.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDisintegrin and metalloproteinase domain-containing protein 17(Homo sapiens (Human))
Dupont Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50102614(7-Isobutyl-8-oxo-2-oxa-9-aza-bicyclo[11.2.2]heptad...)
Affinity DataIC50:  1.00E+3nMAssay Description:Inhibition of LPS-stimulated TNF-alpha release in human whole bloodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed