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BDBM50103072 1-Benzyl-2-piperazin-1-yl-1H-benzoimidazole::CHEMBL56900::Lerisetron

SMILES: C(c1ccccc1)n1c(nc2ccccc12)N1CCNCC1

InChI Key: InChIKey=PWWDCRQZITYKDV-UHFFFAOYSA-N

Data: 2 KI  2 IC50

Find this compound or compounds like it in BindingDB or PDB:
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50103072   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
5-hydroxytryptamine receptor 3A


(Homo sapiens (Human))
BDBM50103072
PNG
(1-Benzyl-2-piperazin-1-yl-1H-benzoimidazole | CHEM...)
Show SMILES C(c1ccccc1)n1c(nc2ccccc12)N1CCNCC1
Show InChI InChI=1S/C18H20N4/c1-2-6-15(7-3-1)14-22-17-9-5-4-8-16(17)20-18(22)21-12-10-19-11-13-21/h1-9,19H,10-14H2
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Article
PubMed
0.360n/an/an/an/an/an/an/an/a



The University of Louisiana at Monroe

Curated by ChEMBL


Assay Description
Binding affinity of the compound against human 5-hydroxytryptamine 3A receptor


Bioorg Med Chem Lett 11: 2133-6 (2001)


Article DOI: 10.1016/s0960-894x(01)00417-6
BindingDB Entry DOI: 10.7270/Q20G3JGG
More data for this
Ligand-Target Pair
Serotonin 3a (5-HT3a)/3b (5-HT3b) receptor


(Rattus norvegicus-RAT)
BDBM50103072
PNG
(1-Benzyl-2-piperazin-1-yl-1H-benzoimidazole | CHEM...)
Show SMILES C(c1ccccc1)n1c(nc2ccccc12)N1CCNCC1
Show InChI InChI=1S/C18H20N4/c1-2-6-15(7-3-1)14-22-17-9-5-4-8-16(17)20-18(22)21-12-10-19-11-13-21/h1-9,19H,10-14H2
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Article
PubMed
0.620n/an/an/an/an/an/an/an/a



Universidad de Alcal£

Curated by ChEMBL


Assay Description
Binding affinity towards rat 5-hydroxytryptamine 3 receptor was evaluated


Bioorg Med Chem Lett 12: 189-92 (2001)


Article DOI: 10.1016/s0960-894x(01)00693-x
BindingDB Entry DOI: 10.7270/Q20R9PX0
More data for this
Ligand-Target Pair
Dopamine D2 receptor/Serotonin 2 (5-HT2) receptor


(Rattus norvegicus (rat))
BDBM50103072
PNG
(1-Benzyl-2-piperazin-1-yl-1H-benzoimidazole | CHEM...)
Show SMILES C(c1ccccc1)n1c(nc2ccccc12)N1CCNCC1
Show InChI InChI=1S/C18H20N4/c1-2-6-15(7-3-1)14-22-17-9-5-4-8-16(17)20-18(22)21-12-10-19-11-13-21/h1-9,19H,10-14H2
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PubMed
n/an/a>1.00E+3n/an/an/an/an/an/a



Universidad de Alcal£

Curated by ChEMBL


Assay Description
Binding affinity towards Dopamine receptor D2 in rat was evaluated


Bioorg Med Chem Lett 12: 189-92 (2001)


Article DOI: 10.1016/s0960-894x(01)00693-x
BindingDB Entry DOI: 10.7270/Q20R9PX0
More data for this
Ligand-Target Pair
HTR4


(GUINEA PIG)
BDBM50103072
PNG
(1-Benzyl-2-piperazin-1-yl-1H-benzoimidazole | CHEM...)
Show SMILES C(c1ccccc1)n1c(nc2ccccc12)N1CCNCC1
Show InChI InChI=1S/C18H20N4/c1-2-6-15(7-3-1)14-22-17-9-5-4-8-16(17)20-18(22)21-12-10-19-11-13-21/h1-9,19H,10-14H2
UniProtKB/SwissProt

GoogleScholar
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Purchase

CHEMBL
PC cid
PC sid
UniChem

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Article
PubMed
n/an/a>1.00E+3n/an/an/an/an/an/a



Universidad de Alcal£

Curated by ChEMBL


Assay Description
Binding affinity towards 5-hydroxytryptamine 4 receptor in striatum membranes of guinea-pig brain was evaluated


Bioorg Med Chem Lett 12: 189-92 (2001)


Article DOI: 10.1016/s0960-894x(01)00693-x
BindingDB Entry DOI: 10.7270/Q20R9PX0
More data for this
Ligand-Target Pair