BDBM50104994 4-tert-Butyl-N-{5-furan-2-yl-6-[2-(5-methylsulfanyl-pyrimidin-2-yloxy)-ethoxy]-pyrimidin-4-yl}-benzenesulfonamide::CHEMBL112502

SMILES CSc1cnc(OCCOc2ncnc(NS(=O)(=O)c3ccc(cc3)C(C)(C)C)c2-c2ccco2)nc1

InChI Key InChIKey=BLWJVNAITNJJCT-UHFFFAOYSA-N

Data  1 IC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50104994   

TargetEndothelin-1 receptor(Sus scrofa)
Tanabe Seiyaku Co., Ltd

Curated by ChEMBL
LigandPNGBDBM50104994(4-tert-Butyl-N-{5-furan-2-yl-6-[2-(5-methylsulfany...)
Show SMILES CSc1cnc(OCCOc2ncnc(NS(=O)(=O)c3ccc(cc3)C(C)(C)C)c2-c2ccco2)nc1
Show InChI InChI=1S/C25H27N5O5S2/c1-25(2,3)17-7-9-19(10-8-17)37(31,32)30-22-21(20-6-5-11-33-20)23(29-16-28-22)34-12-13-35-24-26-14-18(36-4)15-27-24/h5-11,14-16H,12-13H2,1-4H3,(H,28,29,30)
Affinity DataIC50: 2.90nMAssay Description:In vitro inhibition of [125I]-ET-1 binding to Endothelin A receptor in porcine aortic membrane from endothelial cellsMore data for this Ligand-Target Pair