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BDBM50105746 CHEMBL318892::{4-[5-(4-Fluoro-phenyl)-3-(1-methyl-piperidin-4-yl)-3H-imidazol-4-yl]-pyrimidin-2-yl}-phenyl-amine

SMILES: CN1CCC(CC1)n1cnc(c1-c1ccnc(Nc2ccccc2)n1)-c1ccc(F)cc1

InChI Key: InChIKey=DOJXCIZDAFPMQV-UHFFFAOYSA-N

Data: 1 IC50

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Substructure
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50105746   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Mitogen-activated protein kinase 14


(Homo sapiens (Human))
BDBM50105746
PNG
(CHEMBL318892 | {4-[5-(4-Fluoro-phenyl)-3-(1-methyl...)
Show SMILES CN1CCC(CC1)n1cnc(c1-c1ccnc(Nc2ccccc2)n1)-c1ccc(F)cc1
Show InChI InChI=1S/C25H25FN6/c1-31-15-12-21(13-16-31)32-17-28-23(18-7-9-19(26)10-8-18)24(32)22-11-14-27-25(30-22)29-20-5-3-2-4-6-20/h2-11,14,17,21H,12-13,15-16H2,1H3,(H,27,29,30)
PDB
MMDB

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Similars

Article
PubMed
n/an/a 3n/an/an/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Inhibition against Mitogen-activated protein kinase p38 alpha


Bioorg Med Chem Lett 11: 2867-70 (2001)


Article DOI: 10.1016/s0960-894x(01)00570-4
BindingDB Entry DOI: 10.7270/Q28G8K1F
More data for this
Ligand-Target Pair