BDBM50105919 CHEMBL3596632
SMILES [2H]C([2H])([2H])N(C(=O)c1c(F)cccc1Cl)c1ccc(cc1OCC(F)(F)F)-c1cc(ccc1Cl)C(N)=O
InChI Key InChIKey=NVMQCZDBIJGVBJ-FIBGUPNXSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 7 hits for monomerid = 50105919
Affinity DataIC50: 29nMAssay Description:Binding affinity to GST-tagged RORgamma LBD (unknown origin) assessed as inhibition of interaction with co-activatior peptide TRAP220 preincubated fo...More data for this Ligand-Target Pair
Affinity DataEC50: 98nMAssay Description:Inverse agonist activity at RORgamma (unknown origin) transfected in HEK293T cells after 16 to 20 hrs by GAL4 luciferase reporter gene assayMore data for this Ligand-Target Pair
Affinity DataEC50: 895nMAssay Description:Inverse agonist activity at RORgamma in C57BL/6 mouse splenocytes assessed as reduction of IL-17 production after 2 days by ELISAMore data for this Ligand-Target Pair
Affinity DataEC50: 1.93E+3nMAssay Description:Inverse agonist activity at Gal4 DNA binding domain-tagged human RORbeta expressed in HEK293T cells assessed as effect on receptor-mediated transcrip...More data for this Ligand-Target Pair
Affinity DataEC50: 97nMAssay Description:Inverse agonist activity at Gal4 DNA binding domain-tagged human RORgammat expressed in HEK293T cells assessed as effect on receptor-mediated transcr...More data for this Ligand-Target Pair
Affinity DataEC50: 8.36E+3nMAssay Description:Inverse agonist activity at Gal4 DNA binding domain-tagged human RORalpha expressed in HEK293T cells assessed as effect on receptor-mediated transcri...More data for this Ligand-Target Pair
Affinity DataIC50: 29nMAssay Description:Inverse agonist activity at human recombinant GST-tagged RORgammat ligand binding domain assessed as effect on receptor-biotin tagged TRAP220 co-acti...More data for this Ligand-Target Pair