BDBM50107130 (Z)-2-(5-(4-bromobenzylidene)-4-oxo-2-thioxothiazolidin-3-yl)-3-methylbutanoic acid::2-[5-(4-Bromo-benzylidene)-4-oxo-2-thioxo-thiazolidin-3-yl]-3-methyl-butyric acid::CHEMBL335265
SMILES CC(C)C(N1C(=S)S\C(=C/c2ccc(Br)cc2)C1=O)C(O)=O
InChI Key InChIKey=COHIEJLWRGREHV-XFFZJAGNSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 10 hits for monomerid = 50107130
Affinity DataKi: 2.40E+3nMAssay Description:Inhibition of GST-tagged Bcl-xL (unknown origin) measured after 1 hr incubation by fluorescence polarization assayMore data for this Ligand-Target Pair
Affinity DataKi: 2.40E+3nMAssay Description:Inhibition of succinimidyl Oregon Green-labeled Bak-BH3 peptide binding to GST-tagged Bcl-XL (unknown origin) expressed in human Jurkat cells after 1...More data for this Ligand-Target Pair
TargetApoptosis regulator Bcl-2(Homo sapiens (Human))
Georgetown University Medical Center
Curated by ChEMBL
Georgetown University Medical Center
Curated by ChEMBL
Affinity DataKi: 2.40E+3nMAssay Description:Inhibitory activity against Bcl-2More data for this Ligand-Target Pair
Affinity DataKi: 8.70E+3nMAssay Description:Binding affinity to human Bcl-XL by isothermal titration calorimetryMore data for this Ligand-Target Pair
Affinity DataKi: 1.00E+4nMAssay Description:Displacement of fluorescein-labeled Bak-BH3 peptide from human Bcl-XL by fluorescence polarization assayMore data for this Ligand-Target Pair
TargetBcl-2 homologous antagonist/killer(Homo sapiens)
National University Of Ireland Galway
Curated by ChEMBL
National University Of Ireland Galway
Curated by ChEMBL
Affinity DataKi: 4.40E+4nMAssay Description:Binding affinity to Mcl-1/Bak (unknown origin) assessed as inhibition constant by fluorescence polarization assayMore data for this Ligand-Target Pair
TargetBcl-2 homologous antagonist/killer(Homo sapiens)
National University Of Ireland Galway
Curated by ChEMBL
National University Of Ireland Galway
Curated by ChEMBL
Affinity DataIC50: 1.10E+5nMAssay Description:Inhibition of Mcl-1/Bak (unknown origin) by fluorescence polarization assayMore data for this Ligand-Target Pair
TargetBcl-2 homologous antagonist/killer(Homo sapiens)
National University Of Ireland Galway
Curated by ChEMBL
National University Of Ireland Galway
Curated by ChEMBL
Affinity DataKd: 8.40E+4nMAssay Description:Binding affinity to Mcl-1/Bak (unknown origin) assessed as dissociation constant by ITC methodMore data for this Ligand-Target Pair
TargetInduced myeloid leukemia cell differentiation protein Mcl-1(Homo sapiens (Human))
Institute Of Chemical And Engineering Sciences
Curated by ChEMBL
Institute Of Chemical And Engineering Sciences
Curated by ChEMBL
Affinity DataKd: 4.40E+4nMAssay Description:Displacement of fluorescein-labeled Bak-BH3 peptide from human Mcl1 by fluorescence polarization assayMore data for this Ligand-Target Pair
TargetInduced myeloid leukemia cell differentiation protein Mcl-1(Homo sapiens (Human))
Institute Of Chemical And Engineering Sciences
Curated by ChEMBL
Institute Of Chemical And Engineering Sciences
Curated by ChEMBL
Affinity DataKd: 8.40E+4nMAssay Description:Binding affinity to human Mcl1 by isothermal titration calorimetryMore data for this Ligand-Target Pair