BDBM50109637 4-[Ethoxy-(4-methoxy-phenyl)-phosphinoyl]-3-hydroxycarbamoyl-piperazine-1-carboxylic acid benzyl ester::CHEMBL173235

SMILES CCOP(=O)(N1CCN(CC1C(=O)NO)C(=O)OCc1ccccc1)c1ccc(OC)cc1

InChI Key InChIKey=LXKHXLQQHKRMFP-UHFFFAOYSA-N

Data  4 KI  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50109637   

TargetMatrix metalloproteinase-9(Homo sapiens (Human))
Nippon Organon K.K.

Curated by ChEMBL
LigandPNGBDBM50109637(4-[Ethoxy-(4-methoxy-phenyl)-phosphinoyl]-3-hydrox...)
Affinity DataKi:  5.20nMAssay Description:Inhibitory activity against matrix metalloprotease-9 (MMP-9)(gelatinase-B).More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDisintegrin and metalloproteinase domain-containing protein 17(Homo sapiens (Human))
Nippon Organon K.K.

Curated by ChEMBL
LigandPNGBDBM50109637(4-[Ethoxy-(4-methoxy-phenyl)-phosphinoyl]-3-hydrox...)
Affinity DataKi:  7.99nMAssay Description:Inhibitory activity against tumor necrosis factor alpha converting enzyme (TACE) from human acute monocytic leukemia cell line.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetStromelysin-1(Homo sapiens (Human))
Nippon Organon K.K.

Curated by ChEMBL
LigandPNGBDBM50109637(4-[Ethoxy-(4-methoxy-phenyl)-phosphinoyl]-3-hydrox...)
Affinity DataKi:  14.9nMAssay Description:Inhibitory activity against matrix metalloprotease-3 (MMP-3)(stromelysin-1).More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInterstitial collagenase(Homo sapiens (Human))
Nippon Organon K.K.

Curated by ChEMBL
LigandPNGBDBM50109637(4-[Ethoxy-(4-methoxy-phenyl)-phosphinoyl]-3-hydrox...)
Affinity DataKi:  20.1nMAssay Description:Inhibitory activity against matrix metalloprotease-1 (MMP-1)(recombinant human collagenase-1).More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDisintegrin and metalloproteinase domain-containing protein 9(Homo sapiens (Human))
Nippon Organon K.K.

Curated by ChEMBL
LigandPNGBDBM50109637(4-[Ethoxy-(4-methoxy-phenyl)-phosphinoyl]-3-hydrox...)
Affinity DataIC50:  430nMAssay Description:Inhibition of the heparin binding epidermal growth factor (HB-EGF) release from fibrosarcoma HT1080 transfectants expressing alkaline phosphate (AP) ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed