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BDBM50109813 CHEMBL3604152

SMILES: Fc1ccc(NC(=O)c2cc(Cl)[nH]n2)c(Cl)c1

InChI Key: InChIKey=WGWDMYZQEGVYKO-UHFFFAOYSA-N

Data: 2 IC50

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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50109813   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Arachidonate 15-lipoxygenase


(Homo sapiens (Human))
BDBM50109813
PNG
(CHEMBL3604152)
Show SMILES Fc1ccc(NC(=O)c2cc(Cl)[nH]n2)c(Cl)c1
Show InChI InChI=1S/C10H6Cl2FN3O/c11-6-3-5(13)1-2-7(6)14-10(17)8-4-9(12)16-15-8/h1-4H,(H,14,17)(H,15,16)
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PC sid
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Similars

Article
PubMed
n/an/a 22n/an/an/an/an/an/a



Uppsala University

Curated by ChEMBL


Assay Description
Inhibition of 15-LOX-1 in human L1236 cells assessed as reduction in conversion of arachidonic acid to 15-HETE pre-incubated 5 min before arachidonic...


Bioorg Med Chem Lett 25: 3024-9 (2015)


Article DOI: 10.1016/j.bmcl.2015.05.004
BindingDB Entry DOI: 10.7270/Q2R21350
More data for this
Ligand-Target Pair
Arachidonate 15-lipoxygenase


(Homo sapiens (Human))
BDBM50109813
PNG
(CHEMBL3604152)
Show SMILES Fc1ccc(NC(=O)c2cc(Cl)[nH]n2)c(Cl)c1
Show InChI InChI=1S/C10H6Cl2FN3O/c11-6-3-5(13)1-2-7(6)14-10(17)8-4-9(12)16-15-8/h1-4H,(H,14,17)(H,15,16)
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/a 71n/an/an/an/an/an/a



Uppsala University

Curated by ChEMBL


Assay Description
Inhibition of human 15-LOX-1 expressed in Sf9 cells assessed as reduction in conversion of arachidonic acid to 15-HETE pre-incubated 5 min before ara...


Bioorg Med Chem Lett 25: 3024-9 (2015)


Article DOI: 10.1016/j.bmcl.2015.05.004
BindingDB Entry DOI: 10.7270/Q2R21350
More data for this
Ligand-Target Pair