BDBM50113487 CHEMBL3604623

SMILES Clc1cccc(c1)C(=O)Nc1cc(cnc1Cl)-c1ccc2nc(NC3CC3)sc2c1

InChI Key InChIKey=IACDQKWPLBPDSV-UHFFFAOYSA-N

Data  1 IC50

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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50113487   

TargetSmoothened homolog(Mus musculus)
Soochow University

Curated by ChEMBL
LigandPNGBDBM50113487(CHEMBL3604623)
Show SMILES Clc1cccc(c1)C(=O)Nc1cc(cnc1Cl)-c1ccc2nc(NC3CC3)sc2c1
Show InChI InChI=1S/C22H16Cl2N4OS/c23-15-3-1-2-13(8-15)21(29)27-18-9-14(11-25-20(18)24)12-4-7-17-19(10-12)30-22(28-17)26-16-5-6-16/h1-4,7-11,16H,5-6H2,(H,26,28)(H,27,29)
Affinity DataIC50: 150nMAssay Description:Inhibition of SMO in mouse NIH/3T3 cells assessed as inhibition of SAG-induced hedgehog-mediated luminescence signaling by GRE-luciferase reporter ge...More data for this Ligand-Target Pair