BDBM501138 7-((6-(((R)-3- hydroxypyrroli- din-1- yl)methyl)-5- ((R)-THF-3- yl)pyridin-2- yl)amino)-4- (1-methyl-1H- pyrrolo[2,3- b]pyridin-4- yl)-2,3- dihydro-1H- pyrrolo[3,4- c]pyridin-1- one::US11021481, Compound I-810::US11078201, Compound I-810::US11548890, Compound I-810

SMILES Cn1ccc2c(ccnc12)-c1ncc(Nc2ccc([C@H]3CCOC3)c(CN3CC[C@@H](O)C3)n2)c2C(=O)NCc12

InChI Key InChIKey=CGIWBBUBKUCHKG-ZWKOTPCHSA-N

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 501138   

TargetMitogen-activated protein kinase kinase kinase kinase 1(Homo sapiens (Human))
Nimbus Saturn

US Patent
LigandPNGBDBM501138(7-((6-(((R)-3- hydroxypyrroli- din-1- yl)methyl)-5...)
Affinity DataIC50: <100nMAssay Description:HPK1 biochemical enzyme assay: HPK1 enzyme inhibition was measured using a microfluidic mobility shift assay. Reactions were performed in a 384-well ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMitogen-activated protein kinase kinase kinase kinase 1(Homo sapiens (Human))
Nimbus Saturn

US Patent
LigandPNGBDBM501138(7-((6-(((R)-3- hydroxypyrroli- din-1- yl)methyl)-5...)
Affinity DataIC50: <100nMAssay Description:HPK1 biochemical enzyme assay: HPK1 enzyme inhibition was measured using a microfluidic mobility shift assay. Reactions were performed in a 384-well ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMitogen-activated protein kinase kinase kinase kinase 1(Homo sapiens (Human))
Nimbus Saturn

US Patent
LigandPNGBDBM501138(7-((6-(((R)-3- hydroxypyrroli- din-1- yl)methyl)-5...)
Affinity DataIC50: <100nMAssay Description:HPK1 biochemical enzyme assay: HPK1 enzyme inhibition was measured using a microfluidic mobility shift assay. Reactions were performed in a 384-well ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMitogen-activated protein kinase kinase kinase kinase 1(Homo sapiens (Human))
Nimbus Saturn

US Patent
LigandPNGBDBM501138(7-((6-(((R)-3- hydroxypyrroli- din-1- yl)methyl)-5...)
Affinity DataIC50: <100nMAssay Description:HPK1 biochemical enzyme assay: HPK1 enzyme inhibition was measured using a microfluidic mobility shift assay. Reactions were performed in a 384-well ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMitogen-activated protein kinase kinase kinase kinase 1(Homo sapiens (Human))
Nimbus Saturn

US Patent
LigandPNGBDBM501138(7-((6-(((R)-3- hydroxypyrroli- din-1- yl)methyl)-5...)
Affinity DataIC50: <100nMAssay Description:HPK1 biochemical enzyme assay: HPK1 enzyme inhibition was measured using a microfluidic mobility shift assay. Reactions were performed in a 384-well ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent