BDBM50113913 3-[6-(3-Dimethylamino-phenoxy)-3,5-difluoro-4-methyl-pyridin-2-yloxy]-4-hydroxy-benzamidine::CHEMBL82925

SMILES CN(C)c1cccc(Oc2nc(Oc3cc(ccc3O)C(N)=N)c(F)c(C)c2F)c1

InChI Key InChIKey=INIAMHAOELUABG-UHFFFAOYSA-N

Data  4 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50113913   

TargetCoagulation factor X(Homo sapiens (Human))
Yale University

Curated by ChEMBL
LigandPNGBDBM50113913(3-[6-(3-Dimethylamino-phenoxy)-3,5-difluoro-4-meth...)
Affinity DataKi:  3nMAssay Description:Inhibition of human Coagulation factor X was determinedMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Yale University

Curated by ChEMBL
LigandPNGBDBM50113913(3-[6-(3-Dimethylamino-phenoxy)-3,5-difluoro-4-meth...)
Affinity DataKi:  3nMAssay Description:Inhibitory constant against human coagulation factor Xa (fXa)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Berlex Biosciences

Curated by ChEMBL
LigandPNGBDBM50113913(3-[6-(3-Dimethylamino-phenoxy)-3,5-difluoro-4-meth...)
Affinity DataKi:  190nMAssay Description:Inhibitory constant against human coagulation factor II (thrombin) for selectivity within coagulation cascadeMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine protease 1(Homo sapiens (Human))
Berlex Biosciences

Curated by ChEMBL
LigandPNGBDBM50113913(3-[6-(3-Dimethylamino-phenoxy)-3,5-difluoro-4-meth...)
Affinity DataKi:  1.00E+3nMAssay Description:Inhibitory constant against bovine trypsin for general specificity against serine proteasesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed