BDBM50115210 CHEMBL3609011::USRE47740, Compound 19::USRE48547, Compound 19

SMILES CN(Cc1ccc(cc1)B(O)O)c1ncc(cn1)C(=O)Nc1ccc(F)cc1

InChI Key InChIKey=ASWBTVXNCFSFOM-UHFFFAOYSA-N

Data  4 IC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50115210   

TargetC-X-C chemokine receptor type 2(Homo sapiens (Human))
Syntrix Biosystems

Curated by ChEMBL
LigandPNGBDBM50115210(CHEMBL3609011 | USRE47740, Compound 19 | USRE48547...)
Show SMILES CN(Cc1ccc(cc1)B(O)O)c1ncc(cn1)C(=O)Nc1ccc(F)cc1
Show InChI InChI=1S/C19H18BFN4O3/c1-25(12-13-2-4-15(5-3-13)20(27)28)19-22-10-14(11-23-19)18(26)24-17-8-6-16(21)7-9-17/h2-11,27-28H,12H2,1H3,(H,24,26)
Affinity DataIC50: 121nMAssay Description:Antagonist activity at CXCR2 (unknown origin) transfected in RBL cells assessed as inhibition of IL-8-mediated intracellular calcium release preincub...More data for this Ligand-Target Pair
TargetC-X-C chemokine receptor type 2(Homo sapiens (Human))
Syntrix Biosystems

Curated by ChEMBL
LigandPNGBDBM50115210(CHEMBL3609011 | USRE47740, Compound 19 | USRE48547...)
Show SMILES CN(Cc1ccc(cc1)B(O)O)c1ncc(cn1)C(=O)Nc1ccc(F)cc1
Show InChI InChI=1S/C19H18BFN4O3/c1-25(12-13-2-4-15(5-3-13)20(27)28)19-22-10-14(11-23-19)18(26)24-17-8-6-16(21)7-9-17/h2-11,27-28H,12H2,1H3,(H,24,26)
Affinity DataIC50: 244nMAssay Description:An in vitro assay showed inhibition of CXCR2-mediated intracellular calcium release by treatment with compound 9 (IC50=58691 nM). Briefly, human neu...More data for this Ligand-Target Pair
TargetC-X-C chemokine receptor type 2(Homo sapiens (Human))
Syntrix Biosystems

Curated by ChEMBL
LigandPNGBDBM50115210(CHEMBL3609011 | USRE47740, Compound 19 | USRE48547...)
Show SMILES CN(Cc1ccc(cc1)B(O)O)c1ncc(cn1)C(=O)Nc1ccc(F)cc1
Show InChI InChI=1S/C19H18BFN4O3/c1-25(12-13-2-4-15(5-3-13)20(27)28)19-22-10-14(11-23-19)18(26)24-17-8-6-16(21)7-9-17/h2-11,27-28H,12H2,1H3,(H,24,26)
Affinity DataIC50: 244nMAssay Description:Briefly, human neutrophils were suspended in HBSS− (without Ca2+ and Mg2+) containing 10 mM HEPES and FLIPR Calcium 3 dye (3.1107 cells in tot...More data for this Ligand-Target Pair
TargetC-X-C chemokine receptor type 1(Homo sapiens (Human))
Syntrix Biosystems

Curated by ChEMBL
LigandPNGBDBM50115210(CHEMBL3609011 | USRE47740, Compound 19 | USRE48547...)
Show SMILES CN(Cc1ccc(cc1)B(O)O)c1ncc(cn1)C(=O)Nc1ccc(F)cc1
Show InChI InChI=1S/C19H18BFN4O3/c1-25(12-13-2-4-15(5-3-13)20(27)28)19-22-10-14(11-23-19)18(26)24-17-8-6-16(21)7-9-17/h2-11,27-28H,12H2,1H3,(H,24,26)
Affinity DataIC50: 681nMAssay Description:Antagonist activity at CXCR1 (unknown origin) transfected in RBL cells assessed as inhibition of IL-8-mediated intracellular calcium release preincub...More data for this Ligand-Target Pair