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BDBM50115855 2-(3-Ethoxy-2-hydroxy-phenyl)-1H-indole-5-carboxamidine::CHEMBL293657

SMILES: CCOc1cccc(-c2cc3cc(ccc3[nH]2)C(N)=N)c1O

InChI Key: InChIKey=DMULMZBZVBBWBY-UHFFFAOYSA-N

Data: 5 KI

Find this compound or compounds like it in BindingDB or PDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50115855   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Urokinase-type plasminogen activator


(Homo sapiens (Human))
BDBM50115855
PNG
(2-(3-Ethoxy-2-hydroxy-phenyl)-1H-indole-5-carboxam...)
Show SMILES CCOc1cccc(-c2cc3cc(ccc3[nH]2)C(N)=N)c1O
Show InChI InChI=1S/C17H17N3O2/c1-2-22-15-5-3-4-12(16(15)21)14-9-11-8-10(17(18)19)6-7-13(11)20-14/h3-9,20-21H,2H2,1H3,(H3,18,19)
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450n/an/an/an/an/an/an/an/a



Celera

Curated by ChEMBL


Assay Description
Inhibition of urokinase-type plasminogen activator


Bioorg Med Chem Lett 12: 2019-22 (2002)


Article DOI: 10.1016/s0960-894x(02)00311-6
BindingDB Entry DOI: 10.7270/Q237782T
More data for this
Ligand-Target Pair
Plasminogen


(Homo sapiens (Human))
BDBM50115855
PNG
(2-(3-Ethoxy-2-hydroxy-phenyl)-1H-indole-5-carboxam...)
Show SMILES CCOc1cccc(-c2cc3cc(ccc3[nH]2)C(N)=N)c1O
Show InChI InChI=1S/C17H17N3O2/c1-2-22-15-5-3-4-12(16(15)21)14-9-11-8-10(17(18)19)6-7-13(11)20-14/h3-9,20-21H,2H2,1H3,(H3,18,19)
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650n/an/an/an/an/an/an/an/a



Celera

Curated by ChEMBL


Assay Description
Inhibition of plasmin


Bioorg Med Chem Lett 12: 2019-22 (2002)


Article DOI: 10.1016/s0960-894x(02)00311-6
BindingDB Entry DOI: 10.7270/Q237782T
More data for this
Ligand-Target Pair
Tissue-type plasminogen activator


(Homo sapiens (Human))
BDBM50115855
PNG
(2-(3-Ethoxy-2-hydroxy-phenyl)-1H-indole-5-carboxam...)
Show SMILES CCOc1cccc(-c2cc3cc(ccc3[nH]2)C(N)=N)c1O
Show InChI InChI=1S/C17H17N3O2/c1-2-22-15-5-3-4-12(16(15)21)14-9-11-8-10(17(18)19)6-7-13(11)20-14/h3-9,20-21H,2H2,1H3,(H3,18,19)
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1.70E+3n/an/an/an/an/an/an/an/a



Celera

Curated by ChEMBL


Assay Description
Inhibition of tissue-type plasminogen activator


Bioorg Med Chem Lett 12: 2019-22 (2002)


Article DOI: 10.1016/s0960-894x(02)00311-6
BindingDB Entry DOI: 10.7270/Q237782T
More data for this
Ligand-Target Pair
Coagulation factor X


(Homo sapiens (Human))
BDBM50115855
PNG
(2-(3-Ethoxy-2-hydroxy-phenyl)-1H-indole-5-carboxam...)
Show SMILES CCOc1cccc(-c2cc3cc(ccc3[nH]2)C(N)=N)c1O
Show InChI InChI=1S/C17H17N3O2/c1-2-22-15-5-3-4-12(16(15)21)14-9-11-8-10(17(18)19)6-7-13(11)20-14/h3-9,20-21H,2H2,1H3,(H3,18,19)
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2.10E+3n/an/an/an/an/an/an/an/a



Celera

Curated by ChEMBL


Assay Description
Inhibition of Coagulation factor X


Bioorg Med Chem Lett 12: 2019-22 (2002)


Article DOI: 10.1016/s0960-894x(02)00311-6
BindingDB Entry DOI: 10.7270/Q237782T
More data for this
Ligand-Target Pair
Prothrombin


(Homo sapiens (Human))
BDBM50115855
PNG
(2-(3-Ethoxy-2-hydroxy-phenyl)-1H-indole-5-carboxam...)
Show SMILES CCOc1cccc(-c2cc3cc(ccc3[nH]2)C(N)=N)c1O
Show InChI InChI=1S/C17H17N3O2/c1-2-22-15-5-3-4-12(16(15)21)14-9-11-8-10(17(18)19)6-7-13(11)20-14/h3-9,20-21H,2H2,1H3,(H3,18,19)
PDB

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Article
PubMed
9.00E+3n/an/an/an/an/an/an/an/a



Celera

Curated by ChEMBL


Assay Description
Inhibition of thrombin


Bioorg Med Chem Lett 12: 2019-22 (2002)


Article DOI: 10.1016/s0960-894x(02)00311-6
BindingDB Entry DOI: 10.7270/Q237782T
More data for this
Ligand-Target Pair