BDBM50121347 CHEMBL625::THIABENDAZOLE

SMILES c1nc(cs1)-c1nc2ccccc2[nH]1

InChI Key InChIKey=WJCNZQLZVWNLKY-UHFFFAOYSA-N

Data  1 KI  6 IC50  1 Kd  3 EC50

PDB links: 2 PDB IDs match this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 11 hits for monomerid = 50121347   

TargetCytochrome P450 2C9(Homo sapiens (Human))
AstraZeneca R&D

Curated by ChEMBL
LigandPNGBDBM50121347(CHEMBL625 | THIABENDAZOLE)
Affinity DataKi:  2.45E+5nMAssay Description:Binding affinity towards cytochrome P450 2C9More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMethionine aminopeptidase(Escherichia coli (strain K12))
Saarland University

Curated by ChEMBL
LigandPNGBDBM50121347(CHEMBL625 | THIABENDAZOLE)
Affinity DataIC50:  472nMAssay Description:Inhibition of Co2+ loaded MetAP expressed in Escherichia coliMore data for this Ligand-Target Pair
TargetPeptidyl-prolyl cis-trans isomerase FKBP1A(Homo sapiens (Human))
University of California San Diego

Curated by ChEMBL
LigandPNGBDBM50121347(CHEMBL625 | THIABENDAZOLE)
Affinity DataKd:  6.00E+4nMAssay Description:Binding affinity to human FKBP12 expressed in Escherichia coli BL21(DE3) by isothermal titration calorimetryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMethionine aminopeptidase 1(Homo sapiens (Human))
Johns Hopkins University School of Medicine

Curated by ChEMBL
LigandPNGBDBM50121347(CHEMBL625 | THIABENDAZOLE)
Affinity DataEC50:  3.40E+3nMAssay Description:Inhibition of human methionine aminopeptidase 1 in presence of Co2+More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBile salt export pump(Homo sapiens (Human))
AstraZeneca

Curated by ChEMBL
LigandPNGBDBM50121347(CHEMBL625 | THIABENDAZOLE)
Affinity DataIC50:  5.60E+5nMAssay Description:Inhibition of human BSEP expressed in baculovirus transfected fall armyworm Sf21 cell membranes vesicles assessed as reduction in ATP-dependent [3H]-...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMethionine aminopeptidase 1(Homo sapiens (Human))
Johns Hopkins University School of Medicine

Curated by ChEMBL
LigandPNGBDBM50121347(CHEMBL625 | THIABENDAZOLE)
Affinity DataEC50: >1.00E+5nMAssay Description:Inhibition of human methionine aminopeptidase 1 in presence of Mn2+More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMultidrug and toxin extrusion protein 1(Homo sapiens (Human))
University of California

Curated by ChEMBL
LigandPNGBDBM50121347(CHEMBL625 | THIABENDAZOLE)
Affinity DataIC50: >5.00E+5nMAssay Description:Inhibition of human MATE1-mediated ASP+ uptake expressed in HEK293 cells after 1.5 mins by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMethionine aminopeptidase 1(Homo sapiens (Human))
Johns Hopkins University School of Medicine

Curated by ChEMBL
LigandPNGBDBM50121347(CHEMBL625 | THIABENDAZOLE)
Affinity DataIC50:  4.78E+4nMAssay Description:Inhibition of human MetAP1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMethionine aminopeptidase 2(Homo sapiens (Human))
Universit£t Heidelberg

Curated by ChEMBL
LigandPNGBDBM50121347(CHEMBL625 | THIABENDAZOLE)
Affinity DataIC50:  4.47E+4nMAssay Description:Inhibition of human MetAP2 expressed in baculovirus infected Sf9 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReverse transcriptase/RNaseH(Human immunodeficiency virus 1)
Università di Messina

Curated by ChEMBL
LigandPNGBDBM50121347(CHEMBL625 | THIABENDAZOLE)
Affinity DataIC50:  1.46E+4nMAssay Description:HIV-1 reverse transcriptase (RT) activity using Poly (rC)/oligo (dG) as template/primer and [3H]dGTPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMethionine aminopeptidase 1(Homo sapiens (Human))
Johns Hopkins University School of Medicine

Curated by ChEMBL
LigandPNGBDBM50121347(CHEMBL625 | THIABENDAZOLE)
Affinity DataEC50: >2.50E+5nMAssay Description:Inhibition of human methionine aminopeptidase 1 in presence of Zn2+More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed