BDBM50121643 CHEMBL3616847
SMILES [H][C@]12[C@H](C(O)=O)[C@@]1([H])[C@@](N)(C[C@H]2Sc1nnc[nH]1)C(O)=O
InChI Key InChIKey=YSOWRGMLMZQSBX-AVUIYAGVSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 28 hits for monomerid = 50121643
Affinity DataKi: 144nMAssay Description:Displacement of [3H]-459477 from human recombinant mGlu2 receptor expressed in AV12 cells after 90 mins by liquid scintillation countingMore data for this Ligand-Target Pair
Affinity DataKi: 156nMAssay Description:Displacement of [3H]-459477 from human recombinant mGlu3 receptor expressed in AV12 cells after 90 mins by liquid scintillation countingMore data for this Ligand-Target Pair
Affinity DataEC50: 129nMAssay Description:Agonist activity at human recombinant mGlu3 receptor expressed in AV12 cells assessed as inhibition of forskolin-stimulated cAMP production after 1 h...More data for this Ligand-Target Pair
Affinity DataIC50: 2.73E+3nMAssay Description:Antagonist activity at human recombinant mGlu3 receptor expressed in AV12 cells assessed as reversal of DCG-4-inhibited, forskolin-stimulated cAMP pr...More data for this Ligand-Target Pair
Affinity DataEC50: 48nMAssay Description:Agonist activity at human recombinant mGlu2 receptor E273D and L300Q mutant expressed in AV12 cells assessed as stimulation of Ca2+ mobilization afte...More data for this Ligand-Target Pair
Affinity DataEC50: 5.68E+3nMAssay Description:Agonist activity at wild type human recombinant mGlu3 receptor expressed in AV12 cells assessed as stimulation of Ca2+ mobilization after 1 hr by FLI...More data for this Ligand-Target Pair
Affinity DataEC50: 2.18E+3nMAssay Description:Agonist activity at human recombinant mGlu3 receptor D279E mutant expressed in AV12 cells assessed as stimulation of Ca2+ mobilization after 1 hr by ...More data for this Ligand-Target Pair
Affinity DataEC50: 2.83E+3nMAssay Description:Agonist activity at human recombinant mGlu3 receptor Q306L mutant expressed in AV12 cells assessed as stimulation of Ca2+ mobilization after 1 hr by ...More data for this Ligand-Target Pair
Affinity DataEC50: 1.18E+3nMAssay Description:Agonist activity at human recombinant mGlu3 receptor D279E and Q306L mutant expressed in AV12 cells assessed as stimulation of Ca2+ mobilization afte...More data for this Ligand-Target Pair
Affinity DataEC50: >2.50E+4nMAssay Description:Agonist activity at human recombinant mGlu1 receptor expressed in AV12 cells assessed as stimulation of Ca2+ mobilization after 1 hr by FLIPR assayMore data for this Ligand-Target Pair
Affinity DataIC50: >1.25E+4nMAssay Description:Antagonist activity at human recombinant mGlu1 receptor expressed in AV12 cells assessed as inhibition of glutamate-stimulated Ca2+ mobilization afte...More data for this Ligand-Target Pair
Affinity DataEC50: >2.50E+4nMAssay Description:Agonist activity at human recombinant mGlu4 receptor expressed in AV12 cells assessed as stimulation of Ca2+ mobilization after 1 hr by FLIPR assayMore data for this Ligand-Target Pair
Affinity DataIC50: >1.25E+4nMAssay Description:Antagonist activity at human recombinant mGlu4 receptor expressed in AV12 cells assessed as inhibition of glutamate-stimulated Ca2+ mobilization afte...More data for this Ligand-Target Pair
Affinity DataEC50: >2.50E+4nMAssay Description:Agonist activity at human recombinant mGlu5 receptor expressed in AV12 cells assessed as stimulation of Ca2+ mobilization after 1 hr by FLIPR assayMore data for this Ligand-Target Pair
Affinity DataIC50: >1.25E+4nMAssay Description:Antagonist activity at human recombinant mGlu5 receptor expressed in AV12 cells assessed as inhibition of glutamate-stimulated Ca2+ mobilization afte...More data for this Ligand-Target Pair
Affinity DataEC50: 3.45E+3nMAssay Description:Agonist activity at human recombinant mGlu6 receptor expressed in AV12 cells assessed as inhibition of forskolin-stimulated cAMP production after 1 h...More data for this Ligand-Target Pair
Affinity DataEC50: >2.50E+4nMAssay Description:Agonist activity at human recombinant mGlu7 receptor expressed in AV12 cells assessed as stimulation of Ca2+ mobilization after 1 hr by FLIPR assayMore data for this Ligand-Target Pair
Affinity DataIC50: >1.25E+4nMAssay Description:Antagonist activity at human recombinant mGlu7 receptor expressed in AV12 cells assessed as inhibition of glutamate-stimulated Ca2+ mobilization afte...More data for this Ligand-Target Pair
Affinity DataEC50: 1.01E+4nMAssay Description:Agonist activity at human recombinant mGlu8 receptor expressed in AV12 cells assessed as inhibition of forskolin-stimulated cAMP production after 1 h...More data for this Ligand-Target Pair
Affinity DataEC50: >2.50E+4nMAssay Description:Agonist activity at human recombinant mGlu8 receptor expressed in AV12 cells assessed as stimulation of Ca2+ mobilization after 1.5 hrs by FLIPR assa...More data for this Ligand-Target Pair
Affinity DataIC50: >1.25E+4nMAssay Description:Antagonist activity at human recombinant mGlu8 receptor expressed in AV12 cells assessed as inhibition of glutamate-stimulated Ca2+ mobilization afte...More data for this Ligand-Target Pair
Affinity DataEC50: 20nMAssay Description:Agonist activity at wild type human recombinant mGlu2 receptor expressed in AV12 cells assessed as stimulation of Ca2+ mobilization after 1 hr by FLI...More data for this Ligand-Target Pair
Affinity DataEC50: 46nMAssay Description:Agonist activity at human recombinant mGlu2 receptor E273D mutant expressed in AV12 cells assessed as stimulation of Ca2+ mobilization after 1 hr by ...More data for this Ligand-Target Pair
Affinity DataEC50: 22nMAssay Description:Agonist activity at human recombinant mGlu2 receptor L300Q mutant expressed in AV12 cells assessed as stimulation of Ca2+ mobilization after 1 hr by ...More data for this Ligand-Target Pair
Affinity DataEC50: >2.50E+4nMAssay Description:Agonist activity at human recombinant mGlu3 receptor expressed in AV12 cells assessed as stimulation of Ca2+ mobilization after 1.5 hrs by FLIPR assa...More data for this Ligand-Target Pair
Affinity DataIC50: 2.52E+4nMAssay Description:Antagonist activity at human recombinant mGlu3 receptor expressed in AV12 cells assessed as inhibition of glutamate-stimulated Ca2+ mobilization afte...More data for this Ligand-Target Pair
Affinity DataEC50: 5.60nMAssay Description:Agonist activity at human recombinant mGlu2 receptor expressed in AV12 cells assessed as inhibition of forskolin-stimulated cAMP production after 1 h...More data for this Ligand-Target Pair
Affinity DataEC50: 21nMAssay Description:Agonist activity at human recombinant mGlu2 receptor expressed in AV12 cells assessed as stimulation of Ca2+ mobilization after 1 hr by FLIPR assayMore data for this Ligand-Target Pair