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BDBM50121958 4,4'-Biphenyldiol::4,4'-Dihydroxybiphenyl::4,4'-biphenol::4,4'-dioxydiphenyl::CHEMBL76398::DOD::US9688816, 6::[1,1'-biphenyl]-4,4'-diol::biphenyl-4,4'-diol::p,p'-biphenol::p,p'-dihydroxybiphenyl

SMILES: Oc1ccc(cc1)-c1ccc(O)cc1

InChI Key: InChIKey=VCCBEIPGXKNHFW-UHFFFAOYSA-N

Data: 2 IC50  3 Kd

PDB links: 1 PDB ID matches this monomer.

Find this compound or compounds like it in BindingDB:
Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50121958   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Stromelysin-1


(Homo sapiens (Human))
BDBM50121958
PNG
(4,4'-Biphenyldiol | 4,4'-Dihydroxybiphenyl | 4,4'-...)
Show SMILES Oc1ccc(cc1)-c1ccc(O)cc1
Show InChI InChI=1S/C12H10O2/c13-11-5-1-9(2-6-11)10-3-7-12(14)8-4-10/h1-8,13-14H
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Article
PubMed
n/an/an/a 1.50E+5n/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Binding to stromelysin (MMP-3) in the presence of 1-Napthohydroxamate


J Med Chem 45: 5628-39 (2002)


Article DOI: 10.1021/jm020160g
BindingDB Entry DOI: 10.7270/Q20C4V3M
More data for this
Ligand-Target Pair
Stromelysin-1


(Homo sapiens (Human))
BDBM50121958
PNG
(4,4'-Biphenyldiol | 4,4'-Dihydroxybiphenyl | 4,4'-...)
Show SMILES Oc1ccc(cc1)-c1ccc(O)cc1
Show InChI InChI=1S/C12H10O2/c13-11-5-1-9(2-6-11)10-3-7-12(14)8-4-10/h1-8,13-14H
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n/an/an/a 1.60E+5n/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Binding to stromelysin (MMP-3) in the presence of acetohydroxamic acid


J Med Chem 45: 5628-39 (2002)


Article DOI: 10.1021/jm020160g
BindingDB Entry DOI: 10.7270/Q20C4V3M
More data for this
Ligand-Target Pair
Estradiol receptor beta (ERβ)


(Homo sapiens (Human))
BDBM50121958
PNG
(4,4'-Biphenyldiol | 4,4'-Dihydroxybiphenyl | 4,4'-...)
Show SMILES Oc1ccc(cc1)-c1ccc(O)cc1
Show InChI InChI=1S/C12H10O2/c13-11-5-1-9(2-6-11)10-3-7-12(14)8-4-10/h1-8,13-14H
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US Patent
n/an/a 1.70E+3n/an/an/an/an/an/a



SABIC GLOBAL TECHNOLOGIES B.V.

US Patent


Assay Description
Competitive binding assays were performed by incubating rhER alpha (α) and beta 1 (β1) receptors with 10 nM [3H]estradiol (the radio ligand...


US Patent US9688816 (2017)


BindingDB Entry DOI: 10.7270/Q2WD3XR0
More data for this
Ligand-Target Pair
Estrogen receptor


(Homo sapiens (Human))
BDBM50121958
PNG
(4,4'-Biphenyldiol | 4,4'-Dihydroxybiphenyl | 4,4'-...)
Show SMILES Oc1ccc(cc1)-c1ccc(O)cc1
Show InChI InChI=1S/C12H10O2/c13-11-5-1-9(2-6-11)10-3-7-12(14)8-4-10/h1-8,13-14H
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US Patent
n/an/a>2.50E+5n/an/an/an/an/an/a



SABIC GLOBAL TECHNOLOGIES B.V.

US Patent


Assay Description
Competitive binding assays were performed by incubating rhER alpha (α) and beta 1 (β1) receptors with 10 nM [3H]estradiol (the radio ligand...


US Patent US9688816 (2017)


BindingDB Entry DOI: 10.7270/Q2WD3XR0
More data for this
Ligand-Target Pair
GTP-binding protein Rheb


(Homo sapiens (Human))
BDBM50121958
PNG
(4,4'-Biphenyldiol | 4,4'-Dihydroxybiphenyl | 4,4'-...)
Show SMILES Oc1ccc(cc1)-c1ccc(O)cc1
Show InChI InChI=1S/C12H10O2/c13-11-5-1-9(2-6-11)10-3-7-12(14)8-4-10/h1-8,13-14H
PDB
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Article
PubMed
n/an/an/a 1.50E+6n/an/an/an/an/a



Ruhr University of Bochum

Curated by ChEMBL


Assay Description
Binding affinity to full-length Rheb (unknown origin) by NMR spectroscopic analysis


J Med Chem 56: 9664-72 (2014)


Article DOI: 10.1021/jm401291q
BindingDB Entry DOI: 10.7270/Q2959K11
More data for this
Ligand-Target Pair