BDBM50122815 1-(2-{4-[1-(4-Fluoro-phenyl)-5-(2-methyl-2H-tetrazol-5-yl)-1H-indol-3-yl]-piperidin-1-yl}-ethyl)-imidazolidin-2-one::CHEMBL319352

SMILES Cn1nnc(n1)-c1ccc2n(cc(C3CCN(CCN4CCNC4=O)CC3)c2c1)-c1ccc(F)cc1

InChI Key InChIKey=USCDVFNXTCISHV-UHFFFAOYSA-N

Data  21 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 21 hits for monomerid = 50122815   

TargetAlpha-1A adrenergic receptor(CALF)
University Of Copenhagen

Curated by ChEMBL
LigandPNGBDBM50122815(1-(2-{4-[1-(4-Fluoro-phenyl)-5-(2-methyl-2H-tetraz...)
Affinity DataKi:  0.230nMAssay Description:Displacement of [3H]prozosin from bovine cloned alpha1a receptor expressed in BHK cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-1A adrenergic receptor(CALF)
University Of Copenhagen

Curated by ChEMBL
LigandPNGBDBM50122815(1-(2-{4-[1-(4-Fluoro-phenyl)-5-(2-methyl-2H-tetraz...)
Affinity DataKi:  0.230nMAssay Description:Displacement of [3H]prazosine from bovine alpha1A adrenoceptor expressed in BHK cells after 20 mins by scintillation counting analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-1A adrenergic receptor(CALF)
University Of Copenhagen

Curated by ChEMBL
LigandPNGBDBM50122815(1-(2-{4-[1-(4-Fluoro-phenyl)-5-(2-methyl-2H-tetraz...)
Affinity DataKi:  0.230nMAssay Description:Displacement of [3H]prazosin (0.3 nM) from bovine Alpha-1A adrenergic receptor expressed in BHK cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-1B adrenergic receptor(C.H.O.)
University Of Copenhagen

Curated by ChEMBL
LigandPNGBDBM50122815(1-(2-{4-[1-(4-Fluoro-phenyl)-5-(2-methyl-2H-tetraz...)
Affinity DataKi:  1.10nMAssay Description:Displacement of [3H]prozosin from hamster cloned alpha1b receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-1B adrenergic receptor(C.H.O.)
University Of Copenhagen

Curated by ChEMBL
LigandPNGBDBM50122815(1-(2-{4-[1-(4-Fluoro-phenyl)-5-(2-methyl-2H-tetraz...)
Affinity DataKi:  1.10nMAssay Description:Displacement of [3H]prazosine from hamster alpha1B adrenoceptor expressed in Rat1 cells after 20 mins by scintillation counting analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-1B adrenergic receptor(C.H.O.)
University Of Copenhagen

Curated by ChEMBL
LigandPNGBDBM50122815(1-(2-{4-[1-(4-Fluoro-phenyl)-5-(2-methyl-2H-tetraz...)
Affinity DataKi:  1.10nMAssay Description:Displacement of [3H]prazosin (0.5 nM) from hamster Alpha-1B adrenergic receptor expressed in rat-1 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-1D adrenergic receptor(Rattus norvegicus (Rat))
University Of Copenhagen

Curated by ChEMBL
LigandPNGBDBM50122815(1-(2-{4-[1-(4-Fluoro-phenyl)-5-(2-methyl-2H-tetraz...)
Affinity DataKi:  2nMAssay Description:Displacement of [3H]prozosin from rat cloned alpha1d receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-1D adrenergic receptor(Rattus norvegicus (Rat))
University Of Copenhagen

Curated by ChEMBL
LigandPNGBDBM50122815(1-(2-{4-[1-(4-Fluoro-phenyl)-5-(2-methyl-2H-tetraz...)
Affinity DataKi:  2nMAssay Description:Displacement of [3H]prazosin (0.3 nM) from rat Alpha-1D adrenergic receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-1D adrenergic receptor(Rattus norvegicus (Rat))
University Of Copenhagen

Curated by ChEMBL
LigandPNGBDBM50122815(1-(2-{4-[1-(4-Fluoro-phenyl)-5-(2-methyl-2H-tetraz...)
Affinity DataKi:  2nMAssay Description:Displacement of [3H]prazosine from rat alpha1D adrenoceptor expressed in CHO cells after 20 mins by scintillation counting analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1B(Homo sapiens (Human))
H. Lundbeck

Curated by ChEMBL
LigandPNGBDBM50122815(1-(2-{4-[1-(4-Fluoro-phenyl)-5-(2-methyl-2H-tetraz...)
Affinity DataKi:  48nMAssay Description:Ability to displace [3H]5-CT (1.5 nM) from HeLa cells of human 5-hydroxytryptamine 1B receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 2C(Homo sapiens (Human))
University Of Copenhagen

Curated by ChEMBL
LigandPNGBDBM50122815(1-(2-{4-[1-(4-Fluoro-phenyl)-5-(2-methyl-2H-tetraz...)
Affinity DataKi:  60nMAssay Description:Displacement of [3H]prozosin from human cloned 5HT2C receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 2A(Rattus norvegicus (rat))
H. Lundbeck

Curated by ChEMBL
LigandPNGBDBM50122815(1-(2-{4-[1-(4-Fluoro-phenyl)-5-(2-methyl-2H-tetraz...)
Affinity DataKi:  60nMAssay Description:Displacement of [3H]ketanserin (0.5 nM) from rat cerebral cortex 5-hydroxytryptamine 2A receptorsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(1A) dopamine receptor(RAT)
H. Lundbeck

Curated by ChEMBL
LigandPNGBDBM50122815(1-(2-{4-[1-(4-Fluoro-phenyl)-5-(2-methyl-2H-tetraz...)
Affinity DataKi: >100nMAssay Description:Ability to displace [3H]-SCH- 23390 (0.2 nM) from corpus striatum of rat Dopamine receptor D1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1A(Homo sapiens (Human))
H. Lundbeck

Curated by ChEMBL
LigandPNGBDBM50122815(1-(2-{4-[1-(4-Fluoro-phenyl)-5-(2-methyl-2H-tetraz...)
Affinity DataKi:  130nMAssay Description:Ability to displace [3H]5-CT (2.0 nM) from HeLa cells of human 5-hydroxytryptamine 1A receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Rattus norvegicus (rat))
H. Lundbeck

Curated by ChEMBL
LigandPNGBDBM50122815(1-(2-{4-[1-(4-Fluoro-phenyl)-5-(2-methyl-2H-tetraz...)
Affinity DataKi:  140nMAssay Description:Displacement of [3H]spiperone (0.5 nM) from rat corpus striatum dopamine D2 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Homo sapiens (Human))
University Of Copenhagen

Curated by ChEMBL
LigandPNGBDBM50122815(1-(2-{4-[1-(4-Fluoro-phenyl)-5-(2-methyl-2H-tetraz...)
Affinity DataKi:  140nMAssay Description:Displacement of [3H]prozosin from human cloned dopamine D2 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Homo sapiens (Human))
University Of Copenhagen

Curated by ChEMBL
LigandPNGBDBM50122815(1-(2-{4-[1-(4-Fluoro-phenyl)-5-(2-methyl-2H-tetraz...)
Affinity DataKi:  140nMAssay Description:Displacement of [3H]spiperone from human dopamine D2 receptor expressed in CHO cells after 30 mins by scintillation counting analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 2C(Rattus norvegicus (Rat))
H. Lundbeck

Curated by ChEMBL
LigandPNGBDBM50122815(1-(2-{4-[1-(4-Fluoro-phenyl)-5-(2-methyl-2H-tetraz...)
Affinity DataKi:  330nMAssay Description:Displacement of [3H]mesulergine (0.5 nM) from rat 5-hydroxytryptamine 2C receptor expressed in SR-3T3 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H1 receptor(Homo sapiens (Human))
University Of Copenhagen

Curated by ChEMBL
LigandPNGBDBM50122815(1-(2-{4-[1-(4-Fluoro-phenyl)-5-(2-methyl-2H-tetraz...)
Affinity DataKi:  500nMAssay Description:Displacement of [3H]prozosin from human cloned histamine H1 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(3) dopamine receptor(Homo sapiens (Human))
H. Lundbeck

Curated by ChEMBL
LigandPNGBDBM50122815(1-(2-{4-[1-(4-Fluoro-phenyl)-5-(2-methyl-2H-tetraz...)
Affinity DataKi:  1.20E+3nMAssay Description:Ability to displace [3H]spiperone (0.3 nM) from CHO cells of human Dopamine receptor D3More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(4) dopamine receptor(Homo sapiens (Human))
H. Lundbeck

Curated by ChEMBL
LigandPNGBDBM50122815(1-(2-{4-[1-(4-Fluoro-phenyl)-5-(2-methyl-2H-tetraz...)
Affinity DataKi:  4.30E+3nMAssay Description:Displacement of [3H]-YM-09151-2 (0.06 nM) from human Dopamine receptor D4 expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed