BDBM50126732 2-(2,6-Dichloro-phenylamino)-7-(3-diethylamino-propenyl)-1,6-dimethyl-1,8-dihydro-imidazo[4,5-h]isoquinolin-9-one::CHEMBL281957

SMILES CCN(CC)CC=Cc1[nH]c(=O)c2c3n(C)c(Nc4c(Cl)cccc4Cl)nc3ccc2c1C

InChI Key InChIKey=BPLTVYXMXOYIBK-UHFFFAOYSA-N

Data  32 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 32 hits for monomerid = 50126732   

TargetTyrosine-protein kinase Lck(Homo sapiens (Human))
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50126732(2-(2,6-Dichloro-phenylamino)-7-(3-diethylamino-pro...)
Affinity DataIC50:  0.5nMAssay Description:Inhibition of p56 Lck tyrosine kinaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase Lyn(Homo sapiens (Human))
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50126732(2-(2,6-Dichloro-phenylamino)-7-(3-diethylamino-pro...)
Affinity DataIC50:  2nMAssay Description:Inhibition of Protein tyrosine kinase LynMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 1/3(Homo sapiens (Human))
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50126732(2-(2,6-Dichloro-phenylamino)-7-(3-diethylamino-pro...)
Affinity DataIC50: >3.00E+4nMAssay Description:Inhibition of Mitogen-activated protein kinaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetO94806/P05129/P05771/P17252/P24723/P41743/Q02156/Q04759/Q05513/Q05655/Q15139(Homo sapiens (Human))
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50126732(2-(2,6-Dichloro-phenylamino)-7-(3-diethylamino-pro...)
Affinity DataIC50: >3.00E+5nMAssay Description:Inhibition of Protein kinase CMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRho-associated protein kinase 2(Homo sapiens (Human))
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50126732(2-(2,6-Dichloro-phenylamino)-7-(3-diethylamino-pro...)
Affinity DataIC50: >1.00E+3nMAssay Description:Inhibition of Protein kinase ROCK2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInsulin receptor(Homo sapiens (Human))
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50126732(2-(2,6-Dichloro-phenylamino)-7-(3-diethylamino-pro...)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of Insulin receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 11/12/13/14(Homo sapiens (Human))
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50126732(2-(2,6-Dichloro-phenylamino)-7-(3-diethylamino-pro...)
Affinity DataIC50:  150nMAssay Description:Inhibition of Mitogen-activated protein kinase p38More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 1/2/3(Homo sapiens (Human))
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50126732(2-(2,6-Dichloro-phenylamino)-7-(3-diethylamino-pro...)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of Vascular endothelial growth factor receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase Chk1(Homo sapiens (Human))
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50126732(2-(2,6-Dichloro-phenylamino)-7-(3-diethylamino-pro...)
Affinity DataIC50: >1.00E+3nMAssay Description:Inhibition of Serine/threonine-protein kinase Chk1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP-dependent protein kinase catalytic subunit alpha/beta/gamma(Homo sapiens (Human))
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50126732(2-(2,6-Dichloro-phenylamino)-7-(3-diethylamino-pro...)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of Protein kinase A (PKA)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInhibitor of nuclear factor kappa-B kinase subunit alpha(Homo sapiens (Human))
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50126732(2-(2,6-Dichloro-phenylamino)-7-(3-diethylamino-pro...)
Affinity DataIC50:  5.00E+4nMAssay Description:Inhibition of IKK alpha kinaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 10/8/9(Homo sapiens (Human))
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50126732(2-(2,6-Dichloro-phenylamino)-7-(3-diethylamino-pro...)
Affinity DataIC50: >1.00E+3nMAssay Description:Inhibition of c-Jun N-terminal kinaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase ITK/TSK(Homo sapiens (Human))
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50126732(2-(2,6-Dichloro-phenylamino)-7-(3-diethylamino-pro...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of IL-2-inducible T-cell kinase (Itk kinase) was measured using DELFIA (dissociation enhanced lanthanide fluoroimmunoassay)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMAP kinase-activated protein kinase 2(Homo sapiens (Human))
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50126732(2-(2,6-Dichloro-phenylamino)-7-(3-diethylamino-pro...)
Affinity DataIC50: >1.00E+3nMAssay Description:Inhibition of MAP kinase-activated protein kinase 1b/MAP kinase-activated protein kinase 2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase Sgk1(Homo sapiens (Human))
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50126732(2-(2,6-Dichloro-phenylamino)-7-(3-diethylamino-pro...)
Affinity DataIC50: >1.00E+3nMAssay Description:Inhibition of Serum/glucocorticoid regulated kinaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 4(Homo sapiens (Human))
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50126732(2-(2,6-Dichloro-phenylamino)-7-(3-diethylamino-pro...)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of Cyclin-dependent kinase 4More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase ZAP-70(Homo sapiens (Human))
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50126732(2-(2,6-Dichloro-phenylamino)-7-(3-diethylamino-pro...)
Affinity DataIC50:  400nMAssay Description:Inhibition of Zeta-chain (TCR) associated protein kinase 70 kDa (ZAP-70)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50126732(2-(2,6-Dichloro-phenylamino)-7-(3-diethylamino-pro...)
Affinity DataIC50:  0.400nMAssay Description:Inhibition of Brutons tyrosine kinaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRibosomal protein S6 kinase alpha-5(Homo sapiens (Human))
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50126732(2-(2,6-Dichloro-phenylamino)-7-(3-diethylamino-pro...)
Affinity DataIC50: >1.00E+3nMAssay Description:Inhibition of MSK-1 kinaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlycogen synthase kinase-3 beta(Homo sapiens (Human))
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50126732(2-(2,6-Dichloro-phenylamino)-7-(3-diethylamino-pro...)
Affinity DataIC50: >1.00E+3nMAssay Description:Inhibition of Glycogen synthase kinase-3 betaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReceptor tyrosine-protein kinase erbB-2(Homo sapiens (Human))
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50126732(2-(2,6-Dichloro-phenylamino)-7-(3-diethylamino-pro...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of Protein kinase HER-2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50126732(2-(2,6-Dichloro-phenylamino)-7-(3-diethylamino-pro...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of EGFR kinaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase Lck(Homo sapiens (Human))
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50126732(2-(2,6-Dichloro-phenylamino)-7-(3-diethylamino-pro...)
Affinity DataIC50:  0.700nMAssay Description:Inhibition of p56 Lck tyrosine kinaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProto-oncogene tyrosine-protein kinase Src(Homo sapiens (Human))
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50126732(2-(2,6-Dichloro-phenylamino)-7-(3-diethylamino-pro...)
Affinity DataIC50:  0.200nMAssay Description:Inhibition of Src protein tyrosine kinaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase SYK(Homo sapiens (Human))
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50126732(2-(2,6-Dichloro-phenylamino)-7-(3-diethylamino-pro...)
Affinity DataIC50: >4.00E+4nMAssay Description:Inhibition of Syk protein tyrosine kinaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInhibitor of nuclear factor kappa-B kinase subunit beta(Homo sapiens (Human))
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50126732(2-(2,6-Dichloro-phenylamino)-7-(3-diethylamino-pro...)
Affinity DataIC50:  5.00E+4nMAssay Description:Inhibition of IKK beta kinaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 2(Homo sapiens (Human))
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50126732(2-(2,6-Dichloro-phenylamino)-7-(3-diethylamino-pro...)
Affinity DataIC50: >1.00E+3nMAssay Description:Inhibition of Cyclin-dependent kinase 2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHepatocyte growth factor receptor(Homo sapiens (Human))
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50126732(2-(2,6-Dichloro-phenylamino)-7-(3-diethylamino-pro...)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of Hepatocyte growth factor receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRAC-alpha serine/threonine-protein kinase(Homo sapiens (Human))
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50126732(2-(2,6-Dichloro-phenylamino)-7-(3-diethylamino-pro...)
Affinity DataIC50: >1.00E+3nMAssay Description:Inhibition of Protein kinase B alphaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target3-phosphoinositide-dependent protein kinase 1(Homo sapiens (Human))
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50126732(2-(2,6-Dichloro-phenylamino)-7-(3-diethylamino-pro...)
Affinity DataIC50: >1.00E+3nMAssay Description:Inhibition of Phospho-inositide dependent kinase 1 (PDK1)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMAP kinase-activated protein kinase 5(Homo sapiens (Human))
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50126732(2-(2,6-Dichloro-phenylamino)-7-(3-diethylamino-pro...)
Affinity DataIC50: >1.00E+3nMAssay Description:Inhibition of Protein kinase PRAKMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRibosomal protein S6 kinase beta-1/beta-2(Homo sapiens (Human))
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50126732(2-(2,6-Dichloro-phenylamino)-7-(3-diethylamino-pro...)
Affinity DataIC50: >1.00E+3nMAssay Description:Inhibition of Ribosomal protein S6 kinase (P70S6K kinase)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed