BDBM50127480 2-(1,1-Dioxo-7-phenyl-1,3,4,5-tetrahydro-1lambda*6*-benzo[f][1,2,5]thiadiazepin-2-yl)-N-hydroxy-propionamide::CHEMBL298635

SMILES C[C@@H](N1CCNc2cc(ccc2S1(=O)=O)-c1ccccc1)C(=O)NO

InChI Key InChIKey=BNTJDVFEUJBXMT-GFCCVEGCSA-N

Data  4 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50127480   

Target72 kDa type IV collagenase(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50127480(2-(1,1-Dioxo-7-phenyl-1,3,4,5-tetrahydro-1lambda*6...)
Affinity DataKi:  2.80nMAssay Description:In vitro inhibitory activity against broad spectrum matrix metalloprotease-2 (MMP-2)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMatrix metalloproteinase-9(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50127480(2-(1,1-Dioxo-7-phenyl-1,3,4,5-tetrahydro-1lambda*6...)
Affinity DataKi:  8nMAssay Description:In vitro inhibitory activity against broad spectrum matrix metalloprotease-9 (MMP-9)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInterstitial collagenase(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50127480(2-(1,1-Dioxo-7-phenyl-1,3,4,5-tetrahydro-1lambda*6...)
Affinity DataKi:  272nMAssay Description:In vitro inhibitory activity against broad spectrum matrix metalloprotease-1 (MMP-1)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDisintegrin and metalloproteinase domain-containing protein 17(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50127480(2-(1,1-Dioxo-7-phenyl-1,3,4,5-tetrahydro-1lambda*6...)
Affinity DataKi: >1.00E+3nMAssay Description:In vitro inhibitory activity against porcine tumor necrosis factor alpha converting enzyme (pTACE)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed