BDBM50128411 3-desoxy-3-carboxamidonaltrexone::4-cyclopropylmethyl-17-hydroxy-14-oxo-(1S,5R,13R,17S)-12-oxa-4-azapentacyclo[9.6.1.01,13.05,17.07,18]octadeca-7(18),8,10-triene-10-carboxamide::CHEMBL56695

SMILES NC(=O)c1ccc2C[C@H]3N(CC4CC4)CC[C@@]45[C@@H](Oc1c24)C(=O)CC[C@@]35O

InChI Key InChIKey=QAICPHMNUHNDMC-WUHBCXKYSA-N

Data  15 KI  1 IC50  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 17 hits for monomerid = 50128411   

TargetKappa-type opioid receptor(Homo sapiens (Human))
Rensselaer Polytechnic Institute

Curated by ChEMBL
LigandPNGBDBM50128411(3-desoxy-3-carboxamidonaltrexone | 4-cyclopropylme...)
Affinity DataKi:  0.360nMAssay Description:Activity at human cloned kappa opioid receptor expressed in CHO cells by [35S]GTPgammaS binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(Homo sapiens (Human))
Rensselaer Polytechnic Institute

Curated by ChEMBL
LigandPNGBDBM50128411(3-desoxy-3-carboxamidonaltrexone | 4-cyclopropylme...)
Affinity DataKi:  0.710nMAssay Description:Activity at human cloned mu opioid receptor expressed in CHO cells by [35S]GTPgammaS binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(Homo sapiens (Human))
Rensselaer Polytechnic Institute

Curated by ChEMBL
LigandPNGBDBM50128411(3-desoxy-3-carboxamidonaltrexone | 4-cyclopropylme...)
Affinity DataKi:  0.710nMAssay Description:Displacement of [3H]DAMGO from human mu opioid receptor expressed in CHO cells after 60 mins by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(Homo sapiens (Human))
Rensselaer Polytechnic Institute

Curated by ChEMBL
LigandPNGBDBM50128411(3-desoxy-3-carboxamidonaltrexone | 4-cyclopropylme...)
Affinity DataKi:  0.710nMAssay Description:Binding affinity against Opioid receptor mu 1 expressed in CHO cells using [3H]DAMGO as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(GUINEA PIG)
Rensselaer Polytechnic Institute

Curated by ChEMBL
LigandPNGBDBM50128411(3-desoxy-3-carboxamidonaltrexone | 4-cyclopropylme...)
Affinity DataKi:  1.90nMAssay Description:Binding affinity was determined towards opioid receptor mu1 using [3H]-DAMGO as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(GUINEA PIG)
Rensselaer Polytechnic Institute

Curated by ChEMBL
LigandPNGBDBM50128411(3-desoxy-3-carboxamidonaltrexone | 4-cyclopropylme...)
Affinity DataKi:  1.90nMAssay Description:Binding affinity towards Opioid receptor mu 1 of guinea pig brain membranes using radioligand 0.25 nM [3H]DAMGOMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKappa-type opioid receptor(Homo sapiens (Human))
Rensselaer Polytechnic Institute

Curated by ChEMBL
LigandPNGBDBM50128411(3-desoxy-3-carboxamidonaltrexone | 4-cyclopropylme...)
Affinity DataKi:  11nMAssay Description:Binding affinity against Opioid receptor kappa 1 expressed in CHO cells using [3H]U-69593 as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKappa-type opioid receptor(Homo sapiens (Human))
Rensselaer Polytechnic Institute

Curated by ChEMBL
LigandPNGBDBM50128411(3-desoxy-3-carboxamidonaltrexone | 4-cyclopropylme...)
Affinity DataKi:  11nMAssay Description:Displacement of [3H]U69,593 from human kappa opioid receptor expressed in CHO cells after 60 mins by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKappa-type opioid receptor(Cavia porcellus (domestic guinea pig))
Pharmacia

Curated by ChEMBL
LigandPNGBDBM50128411(3-desoxy-3-carboxamidonaltrexone | 4-cyclopropylme...)
Affinity DataKi:  22nMAssay Description:Binding affinity towards guinea pig Opioid receptor kappa 1 using radioligand [3H]U-69593More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKappa-type opioid receptor(Cavia porcellus (domestic guinea pig))
Pharmacia

Curated by ChEMBL
LigandPNGBDBM50128411(3-desoxy-3-carboxamidonaltrexone | 4-cyclopropylme...)
Affinity DataKi:  22nMAssay Description:Binding affinity was determined towards opioid receptor kappa 1 using [3H]U69,593 as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDelta-type opioid receptor(Homo sapiens (Human))
Pharmacia

Curated by ChEMBL
LigandPNGBDBM50128411(3-desoxy-3-carboxamidonaltrexone | 4-cyclopropylme...)
Affinity DataKi:  110nMAssay Description:Binding affinity towards Opioid receptor delta 1 of guinea pig brain membranes using radioligand 0.2 nM [3H]NaltrindoleMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDelta-type opioid receptor(Homo sapiens (Human))
Pharmacia

Curated by ChEMBL
LigandPNGBDBM50128411(3-desoxy-3-carboxamidonaltrexone | 4-cyclopropylme...)
Affinity DataKi:  110nMAssay Description:Binding affinity was determined towards Opioid receptor delta 1 using [3H]-Naltrindole as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDelta-type opioid receptor(Homo sapiens (Human))
Pharmacia

Curated by ChEMBL
LigandPNGBDBM50128411(3-desoxy-3-carboxamidonaltrexone | 4-cyclopropylme...)
Affinity DataKi:  550nMAssay Description:Displacement of [3H]naltrindole from human delta opioid receptor expressed in CHO cells after 3 hrs by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDelta-type opioid receptor(Homo sapiens (Human))
Pharmacia

Curated by ChEMBL
LigandPNGBDBM50128411(3-desoxy-3-carboxamidonaltrexone | 4-cyclopropylme...)
Affinity DataKi:  550nMAssay Description:Displacement of [3H]Naltrindole form human delta opioid receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDelta-type opioid receptor(Homo sapiens (Human))
Pharmacia

Curated by ChEMBL
LigandPNGBDBM50128411(3-desoxy-3-carboxamidonaltrexone | 4-cyclopropylme...)
Affinity DataKi:  550nMAssay Description:Binding affinity against Opioid receptor delta 1 expressed in CHO cells using [3H]Naltrindole as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(Homo sapiens (Human))
Rensselaer Polytechnic Institute

Curated by ChEMBL
LigandPNGBDBM50128411(3-desoxy-3-carboxamidonaltrexone | 4-cyclopropylme...)
Affinity DataIC50:  270nMAssay Description:Antagonist activity against human mu opioid receptor expressed in CHO cells assessed as inhibition of DAMGO-stimulated [35S]GTPgammaS bindingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(Homo sapiens (Human))
Rensselaer Polytechnic Institute

Curated by ChEMBL
LigandPNGBDBM50128411(3-desoxy-3-carboxamidonaltrexone | 4-cyclopropylme...)
Affinity DataEC50:  4.90nMAssay Description:Agonist activity at human mu opioid receptor expressed in CHO cells assessed as stimulation of [35S]GTPgammaS bindingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed