BDBM50130725 3-(3-Chloro-4-hydroxy-phenylamino)-4-(2-nitro-phenyl)-pyrrole-2,5-dione::3-(3-chloro-4-hydroxyphenylamino)-4-(2-nitrophenyl)-1H-pyrrole-2,5-dione::CHEMBL322970::SB-415286::SB415286::cid_4210951
SMILES Oc1ccc(NC2=C(C(=O)NC2=O)c2ccccc2[N+]([O-])=O)cc1Cl
InChI Key InChIKey=PQCXVIPXISBFPN-UHFFFAOYSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 14 hits for monomerid = 50130725
Affinity DataKi: 24nMAssay Description:Inhibition of GSK3-beta assessed as NADH level after 10 mins by pyruvate kinase/lactate dehydrogenase coupled spectrophotometric assayMore data for this Ligand-Target Pair
TargetSerine/threonine-protein kinase/endoribonuclease IRE1 [547-977](Homo sapiens (Human))
University Of Washington
University Of Washington
Affinity DataIC50: 1.30E+3nMpH: 7.5Assay Description:Inhibitors (initial concentration 10 or 60 μM, three-fold serial dilutions) were incubated with IRE1α* in cleavage buffer (20 mM HEPES at p...More data for this Ligand-Target Pair
Affinity DataIC50: 78nMAssay Description:Inhibition of human GSK3betaMore data for this Ligand-Target Pair
TargetCyclin-A1/Cyclin-A2/Cyclin-dependent kinase 2(Homo sapiens (Human))
Novo Nordisk
Curated by ChEMBL
Novo Nordisk
Curated by ChEMBL
Affinity DataIC50: 380nMAssay Description:Inhibition of Cyclin-dependent kinase 2-cyclin AMore data for this Ligand-Target Pair
Affinity DataIC50: 380nMAssay Description:Inhibitory activity against human glycogen synthase kinase-3beta (GSK3-beta) at 100 uM ATPMore data for this Ligand-Target Pair
Affinity DataIC50: 104nMAssay Description:Inhibition of recombinant GSK3-betaMore data for this Ligand-Target Pair
Affinity DataIC50: 34nMAssay Description:Inhibition of GSK-3beta (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 90nMAssay Description:Inhibition of GSK3-beta by luminescent assayMore data for this Ligand-Target Pair
TargetCyclin-dependent kinase 1/G2/mitotic-specific cyclin-B1/G2/mitotic-specific cyclin-B2/G2/mitotic-specific cyclin-B3(Homo sapiens (Human))
The Rockefeller University
Curated by ChEMBL
The Rockefeller University
Curated by ChEMBL
Affinity DataIC50: 900nMAssay Description:Inhibition of CDK1/cyclinBMore data for this Ligand-Target Pair
TargetGlycogen synthase kinase-3 alpha(Homo sapiens (Human))
The Rockefeller University
Curated by ChEMBL
The Rockefeller University
Curated by ChEMBL
Affinity DataIC50: 78nMAssay Description:Inhibition of GSK3alphaMore data for this Ligand-Target Pair
Affinity DataIC50: 50nMAssay Description:Inhibition of human recombinant GSK3beta using GSM as substrate incubated for 30 mins by luminescence based assayMore data for this Ligand-Target Pair
Affinity DataIC50: 54nMAssay Description:Inhibition of human full length GSK3beta expressed in baculovirus in Sf9 insect cells using YRRAAVPPSPSLSRHSSPHQ(pS)EDEEE as substrate by ADP-Glo kin...More data for this Ligand-Target Pair
Affinity DataEC50: 239nMAssay Description:Keywords: GSK3beta, dose response, kinase, inhibition, HTS Assay Overview: The glycogen synthase kinase-3 beta (GSK-3b) is a known master regulator f...More data for this Ligand-Target Pair
Affinity DataIC50: 77nMAssay Description:Inhibition of human recombinant GSK3-beta assessed as [gamma33]ATP transfer to biotinylated CREB-peptide substrate after 1 hr by scintillation counti...More data for this Ligand-Target Pair