BDBM50131441 9,13b-dihydro-1H-dibenzo[c,f]imidazo[1,5-a]azepin-3-amine::CHEMBL1106::EPINASTINE::Elestat::Flurinol::WAL 80::WAL 801::epinastine hydrochloride

SMILES NC1=NCC2N1c1ccccc1Cc1ccccc21

InChI Key InChIKey=WHWZLSFABNNENI-UHFFFAOYSA-N

Data  7 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 50131441   

TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Gedeon Richter Ltd

Curated by ChEMBL
LigandPNGBDBM50131441(9,13b-dihydro-1H-dibenzo[c,f]imidazo[1,5-a]azepin-...)
Affinity DataIC50:  1.00E+5nMAssay Description:Inhibition of human Potassium channel HERG expressed in mammalian cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMultidrug and toxin extrusion protein 2(Homo sapiens (Human))
University of California

Curated by ChEMBL
LigandPNGBDBM50131441(9,13b-dihydro-1H-dibenzo[c,f]imidazo[1,5-a]azepin-...)
Affinity DataIC50:  2.98E+4nMAssay Description:Inhibition of human MATE2K-mediated ASP+ uptake expressed in HEK293 cells after 1.5 mins by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSolute carrier family 22 member 2(Homo sapiens (Human))
University of California

Curated by ChEMBL
LigandPNGBDBM50131441(9,13b-dihydro-1H-dibenzo[c,f]imidazo[1,5-a]azepin-...)
Affinity DataIC50:  4.30E+3nMAssay Description:Inhibition of human OCT2-mediated ASP+ uptake expressed in HEK293 cells after 3 mins by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H1 receptor(Cavia porcellus (domestic guinea pig))
Vrije Universiteit

Curated by ChEMBL
LigandPNGBDBM50131441(9,13b-dihydro-1H-dibenzo[c,f]imidazo[1,5-a]azepin-...)
Affinity DataIC50:  1.58nMAssay Description:Potency against histamine H1 receptor on guinea pig ileumMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Gedeon Richter Ltd

Curated by ChEMBL
LigandPNGBDBM50131441(9,13b-dihydro-1H-dibenzo[c,f]imidazo[1,5-a]azepin-...)
Affinity DataIC50:  9.12E+4nMAssay Description:Inhibitory concentration against potassium channel HERGMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Gedeon Richter Ltd

Curated by ChEMBL
LigandPNGBDBM50131441(9,13b-dihydro-1H-dibenzo[c,f]imidazo[1,5-a]azepin-...)
Affinity DataIC50:  1.00E+5nMAssay Description:Inhibition of human ERG expressed in CHO cells by whole cell patch clamp techniqueMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMultidrug and toxin extrusion protein 1(Homo sapiens (Human))
University of California

Curated by ChEMBL
LigandPNGBDBM50131441(9,13b-dihydro-1H-dibenzo[c,f]imidazo[1,5-a]azepin-...)
Affinity DataIC50:  1.10E+3nMAssay Description:Inhibition of human MATE1-mediated ASP+ uptake expressed in HEK293 cells after 1.5 mins by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed