BDBM50132069 3-(4-Fluoro-phenyl)-N-{4-[4-(2-methoxy-phenyl)-piperazin-1-yl]-butyl}-acrylamide::CHEMBL338606

SMILES COc1ccccc1N1CCN(CCCCNC(=O)\C=C\c2ccc(F)cc2)CC1

InChI Key InChIKey=ZIAICQQANCNQNU-JLHYYAGUSA-N

Data  7 KI  2 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 9 hits for monomerid = 50132069   

TargetD(3) dopamine receptor(Homo sapiens (Human))
Friedrich-Alexander-UniversitäT Erlangen-NüRnberg

Curated by ChEMBL
LigandPNGBDBM50132069(3-(4-Fluoro-phenyl)-N-{4-[4-(2-methoxy-phenyl)-pip...)
Affinity DataKi:  0.340nMAssay Description:Displacement of [3H]spiperone from human dopamine D3 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(3) dopamine receptor(Homo sapiens (Human))
Friedrich-Alexander-UniversitäT Erlangen-NüRnberg

Curated by ChEMBL
LigandPNGBDBM50132069(3-(4-Fluoro-phenyl)-N-{4-[4-(2-methoxy-phenyl)-pip...)
Affinity DataKi:  0.690nMAssay Description:Binding affinity for human dopamine receptor D3 by displacing [125I]-iodosulpiride expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Homo sapiens (Human))
Johann Wolfgang Goethe-UniversitäT

Curated by ChEMBL
LigandPNGBDBM50132069(3-(4-Fluoro-phenyl)-N-{4-[4-(2-methoxy-phenyl)-pip...)
Affinity DataKi:  20.7nMAssay Description:Binding affinity for human dopamine receptor D2 by displacing [125I]-iodosulpiride expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Homo sapiens (Human))
Johann Wolfgang Goethe-UniversitäT

Curated by ChEMBL
LigandPNGBDBM50132069(3-(4-Fluoro-phenyl)-N-{4-[4-(2-methoxy-phenyl)-pip...)
Affinity DataKi:  21nMAssay Description:Displacement of [3H]spiperone from human dopamine D2short receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Homo sapiens (Human))
Johann Wolfgang Goethe-UniversitäT

Curated by ChEMBL
LigandPNGBDBM50132069(3-(4-Fluoro-phenyl)-N-{4-[4-(2-methoxy-phenyl)-pip...)
Affinity DataKi:  27nMAssay Description:Displacement of [3H]spiperone from human dopamine D2long receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 2A(PIG)
Friedrich-Alexander-UniversitäT Erlangen-NüRnberg

Curated by ChEMBL
LigandPNGBDBM50132069(3-(4-Fluoro-phenyl)-N-{4-[4-(2-methoxy-phenyl)-pip...)
Affinity DataKi:  330nMAssay Description:Displacement of [3H]ketanserin from 5-HT2 receptor in porcine cerebral cortex membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(1A) dopamine receptor(Sus scrofa)
Friedrich-Alexander-UniversitäT Erlangen-NüRnberg

Curated by ChEMBL
LigandPNGBDBM50132069(3-(4-Fluoro-phenyl)-N-{4-[4-(2-methoxy-phenyl)-pip...)
Affinity DataKi:  1.10E+3nMAssay Description:Displacement of [3H]SCH 23990 from dopamine D1 receptor in porcine cerebral cortex membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Homo sapiens (Human))
Johann Wolfgang Goethe-UniversitäT

Curated by ChEMBL
LigandPNGBDBM50132069(3-(4-Fluoro-phenyl)-N-{4-[4-(2-methoxy-phenyl)-pip...)
Affinity DataEC50:  1.70nMAssay Description:Agonist activity at human dopamine receptor D2long expressed in CHO10001 cells assessed as stimulation of incorporation [3H]-thymidine incorporationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(3) dopamine receptor(Homo sapiens (Human))
Friedrich-Alexander-UniversitäT Erlangen-NüRnberg

Curated by ChEMBL
LigandPNGBDBM50132069(3-(4-Fluoro-phenyl)-N-{4-[4-(2-methoxy-phenyl)-pip...)
Affinity DataEC50:  3.90nMAssay Description:Agonist activity at human dopamine D3 receptor expressed in CHO dhfr-negative cells assessed as stimulation of [3H]-thymidine incorporationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed