BDBM50133229 1-Methyl-2-(3,7,8,9-tetrahydro-pyrano[3,2-e]indol-1-yl)-ethylamine::CHEMBL133868

SMILES CC(N)Cc1c[nH]c2ccc3OCCCc3c12

InChI Key InChIKey=VVHJUSGIUWQPIT-UHFFFAOYSA-N

Data  16 KI  4 IC50  2 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 22 hits for monomerid = 50133229   

Target5-hydroxytryptamine receptor 2A(Rattus norvegicus (rat))
Alcon Research

Curated by ChEMBL
LigandPNGBDBM50133229(1-Methyl-2-(3,7,8,9-tetrahydro-pyrano[3,2-e]indol-...)
Affinity DataKi:  0.300nMAssay Description:In vitro inhibitory constant against [125I]DOI binding to 5-hydroxytryptamine 2A receptor in rat cerebral cortexMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 2A(Homo sapiens (Human))
Alcon Research

Curated by ChEMBL
LigandPNGBDBM50133229(1-Methyl-2-(3,7,8,9-tetrahydro-pyrano[3,2-e]indol-...)
Affinity DataKi:  3.60nMAssay Description:Inhibitory constant against cloned human 5-hydroxytryptamine 2A receptor using with [125I]- DOI radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 2C(Homo sapiens (Human))
Alcon Research

Curated by ChEMBL
LigandPNGBDBM50133229(1-Methyl-2-(3,7,8,9-tetrahydro-pyrano[3,2-e]indol-...)
Affinity DataKi:  5.5nMAssay Description:Inhibitory constant against cloned human 5-hydroxytryptamine 2C receptor using with [125I]- DOI radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 2B(Homo sapiens (Human))
Alcon Research

Curated by ChEMBL
LigandPNGBDBM50133229(1-Methyl-2-(3,7,8,9-tetrahydro-pyrano[3,2-e]indol-...)
Affinity DataKi:  13nMAssay Description:Inhibitory constant against cloned human 5-hydroxytryptamine 2B receptor using with [125I]- DOI radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 6(Homo sapiens (Human))
Alcon Research

Curated by ChEMBL
LigandPNGBDBM50133229(1-Methyl-2-(3,7,8,9-tetrahydro-pyrano[3,2-e]indol-...)
Affinity DataKi:  400nMAssay Description:Inhibitory constant against human 5-hydroxytryptamine 6 receptor using [3H]LSD radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 4(Homo sapiens (Human))
Alcon Research

Curated by ChEMBL
LigandPNGBDBM50133229(1-Methyl-2-(3,7,8,9-tetrahydro-pyrano[3,2-e]indol-...)
Affinity DataKi:  1.80E+3nMAssay Description:Inhibitory constant against 5-hydroxytryptamine 4 receptor using [3H]GR-113808 radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1D(Homo sapiens (Human))
Alcon Research

Curated by ChEMBL
LigandPNGBDBM50133229(1-Methyl-2-(3,7,8,9-tetrahydro-pyrano[3,2-e]indol-...)
Affinity DataKi:  1.90E+3nMAssay Description:Inhibitory constant against human 5-hydroxytryptamine 5A receptor using [3H]LSD radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-2B adrenergic receptor(NEONATAL RAT)
Alcon Research

Curated by ChEMBL
LigandPNGBDBM50133229(1-Methyl-2-(3,7,8,9-tetrahydro-pyrano[3,2-e]indol-...)
Affinity DataKi:  1.00E+4nMAssay Description:Inhibitory constant against Alpha-2B adrenergic receptor using [3H]MK-912 radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 5A(Homo sapiens (Human))
Alcon Research

Curated by ChEMBL
LigandPNGBDBM50133229(1-Methyl-2-(3,7,8,9-tetrahydro-pyrano[3,2-e]indol-...)
Affinity DataKi: >1.00E+4nMAssay Description:Inhibitory constant against human 5-hydroxytryptamine 1B receptor using [3H]5-CT radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
Alcon Research

Curated by ChEMBL
LigandPNGBDBM50133229(1-Methyl-2-(3,7,8,9-tetrahydro-pyrano[3,2-e]indol-...)
Affinity DataKi: >1.00E+4nMAssay Description:Inhibitory constant against human serotonin transporter using [3H]N-Me-citalopram radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 3A(Homo sapiens (Human))
Alcon Research

Curated by ChEMBL
LigandPNGBDBM50133229(1-Methyl-2-(3,7,8,9-tetrahydro-pyrano[3,2-e]indol-...)
Affinity DataKi: >1.00E+4nMAssay Description:Inhibitory constant against 5-hydroxytryptamine 3 receptor using [3H]GR-65630 radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1B(Homo sapiens (Human))
Alcon Research

Curated by ChEMBL
LigandPNGBDBM50133229(1-Methyl-2-(3,7,8,9-tetrahydro-pyrano[3,2-e]indol-...)
Affinity DataKi: >1.00E+4nMAssay Description:Inhibitory constant against 5-hydroxytryptamine 1B receptor using with [125I]- cyanopindolol radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 7(Homo sapiens (Human))
Alcon Research

Curated by ChEMBL
LigandPNGBDBM50133229(1-Methyl-2-(3,7,8,9-tetrahydro-pyrano[3,2-e]indol-...)
Affinity DataKi:  2.40E+4nMAssay Description:Inhibitory constant against human 5-hydroxytryptamine 7 receptor using [3H]LSD radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-1A adrenergic receptor(Rattus norvegicus (Rat))
Alcon Research

Curated by ChEMBL
LigandPNGBDBM50133229(1-Methyl-2-(3,7,8,9-tetrahydro-pyrano[3,2-e]indol-...)
Affinity DataKi: >3.00E+4nMAssay Description:Inhibitory constant against Alpha-1A adrenergic receptor using [3H]-7-MeO prazosin radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent noradrenaline transporter(Homo sapiens (Human))
Alcon Research

Curated by ChEMBL
LigandPNGBDBM50133229(1-Methyl-2-(3,7,8,9-tetrahydro-pyrano[3,2-e]indol-...)
Affinity DataKi: >3.00E+4nMAssay Description:Inhibitory constant against norepinephrine transporter receptor using [3H]radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-1A adrenergic receptor(Rattus norvegicus (Rat))
Alcon Research

Curated by ChEMBL
LigandPNGBDBM50133229(1-Methyl-2-(3,7,8,9-tetrahydro-pyrano[3,2-e]indol-...)
Affinity DataKi: >3.00E+4nMAssay Description:Inhibitory constant against Alpha-1B adrenergic receptor using [3H]-7-MeO prazosin radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 2A(Homo sapiens (Human))
Alcon Research

Curated by ChEMBL
LigandPNGBDBM50133229(1-Methyl-2-(3,7,8,9-tetrahydro-pyrano[3,2-e]indol-...)
Affinity DataIC50:  1.09E+4nMAssay Description:In vitro inhibitory concentration required against [3H]8-OH-DPAT binding to cloned human 5-hydroxytryptamine 1A receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 2A(Rattus norvegicus (rat))
Alcon Research

Curated by ChEMBL
LigandPNGBDBM50133229(1-Methyl-2-(3,7,8,9-tetrahydro-pyrano[3,2-e]indol-...)
Affinity DataEC50:  116nMAssay Description:In vitro relative agonist activity against 5-hydroxytryptamine 2A using PI assay in rat vascular smooth muscle cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1A(Homo sapiens (Human))
Alcon Research

Curated by ChEMBL
LigandPNGBDBM50133229(1-Methyl-2-(3,7,8,9-tetrahydro-pyrano[3,2-e]indol-...)
Affinity DataEC50: >1.00E+4nMAssay Description:Tested for functional response on CHO cells expressing cloned human 5-hydroxytryptamine 1A receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-2A adrenergic receptor(Homo sapiens (Human))
Alcon Research

Curated by ChEMBL
LigandPNGBDBM50133229(1-Methyl-2-(3,7,8,9-tetrahydro-pyrano[3,2-e]indol-...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibitory concentration required against Alpha-2A adrenergic receptor using [3H]clonidine radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 2A(Rattus norvegicus (rat))
Alcon Research

Curated by ChEMBL
LigandPNGBDBM50133229(1-Methyl-2-(3,7,8,9-tetrahydro-pyrano[3,2-e]indol-...)
Affinity DataIC50:  0.700nMAssay Description:In vitro inhibition of [125I]DOI binding to 5-hydroxytryptamine 2A receptor in rat cerebral cortexMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-2C adrenergic receptor(Homo sapiens (Human))
Alcon Research

Curated by ChEMBL
LigandPNGBDBM50133229(1-Methyl-2-(3,7,8,9-tetrahydro-pyrano[3,2-e]indol-...)
Affinity DataIC50: >3.00E+4nMAssay Description:Inhibitory concentration required against Alpha-2C adrenergic receptor using [3H]clonidine radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed