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BDBM50133737 1-(3-Cyano-1H-indol-6-yl)-3-p-tolyl-urea::CHEMBL118306

SMILES: Cc1ccc(NC(=O)Nc2ccc3c(c[nH]c3c2)C#N)cc1

InChI Key: InChIKey=NYLVLOBQOCWIPM-UHFFFAOYSA-N

Data: 1 IC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50133737   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Inosine Monophosphate Dehydrogenase Type 2 (IMPDH2)


(Homo sapiens (Human))
BDBM50133737
PNG
(1-(3-Cyano-1H-indol-6-yl)-3-p-tolyl-urea | CHEMBL1...)
Show SMILES Cc1ccc(NC(=O)Nc2ccc3c(c[nH]c3c2)C#N)cc1
Show InChI InChI=1S/C17H14N4O/c1-11-2-4-13(5-3-11)20-17(22)21-14-6-7-15-12(9-18)10-19-16(15)8-14/h2-8,10,19H,1H3,(H2,20,21,22)
PDB
MMDB

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Similars

Article
PubMed
n/an/a>5.00E+6n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibitory activity tested against inosine-5'-monophosphate dehydrogenase 2 (IMPDH-II) enzyme


Bioorg Med Chem Lett 13: 3557-60 (2003)


Article DOI: 10.1016/s0960-894x(03)00757-1
BindingDB Entry DOI: 10.7270/Q2J67G94
More data for this
Ligand-Target Pair