BDBM50133928 1-(4-Fluoro-phenyl)-4-(1,2,4,4a,5,6-hexahydro-pyrazino[1,2-a]quinolin-3-yl)-butan-1-one::CHEMBL341774

SMILES Fc1ccc(cc1)C(=O)CCCN1CCN2C(CCc3ccccc23)C1

InChI Key InChIKey=CDMKFCYALGWSEN-UHFFFAOYSA-N

Data  5 KI

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50133928   

TargetD(3) dopamine receptor(Homo sapiens (Human))
University of Michigan

Curated by ChEMBL
LigandPNGBDBM50133928(1-(4-Fluoro-phenyl)-4-(1,2,4,4a,5,6-hexahydro-pyra...)
Show SMILES Fc1ccc(cc1)C(=O)CCCN1CCN2C(CCc3ccccc23)C1
Show InChI InChI=1S/C22H25FN2O/c23-19-10-7-18(8-11-19)22(26)6-3-13-24-14-15-25-20(16-24)12-9-17-4-1-2-5-21(17)25/h1-2,4-5,7-8,10-11,20H,3,6,9,12-16H2
Affinity DataKi:  83.5nMAssay Description:Ability to compete with [3H]YM-09151-2 binding to the human dopamine receptor D3 transfected in CHO cellsMore data for this Ligand-Target Pair
TargetD(4) dopamine receptor(RAT)
University of Michigan

Curated by ChEMBL
LigandPNGBDBM50133928(1-(4-Fluoro-phenyl)-4-(1,2,4,4a,5,6-hexahydro-pyra...)
Show SMILES Fc1ccc(cc1)C(=O)CCCN1CCN2C(CCc3ccccc23)C1
Show InChI InChI=1S/C22H25FN2O/c23-19-10-7-18(8-11-19)22(26)6-3-13-24-14-15-25-20(16-24)12-9-17-4-1-2-5-21(17)25/h1-2,4-5,7-8,10-11,20H,3,6,9,12-16H2
Affinity DataKi:  243nMAssay Description:Inhibition of [3H]-Spiperone binding to Dopamine receptor D2-like in rat caudate-putamen membraneMore data for this Ligand-Target Pair
TargetD(3) dopamine receptor(Rattus norvegicus (Rat))
University of Michigan

Curated by ChEMBL
LigandPNGBDBM50133928(1-(4-Fluoro-phenyl)-4-(1,2,4,4a,5,6-hexahydro-pyra...)
Show SMILES Fc1ccc(cc1)C(=O)CCCN1CCN2C(CCc3ccccc23)C1
Show InChI InChI=1S/C22H25FN2O/c23-19-10-7-18(8-11-19)22(26)6-3-13-24-14-15-25-20(16-24)12-9-17-4-1-2-5-21(17)25/h1-2,4-5,7-8,10-11,20H,3,6,9,12-16H2
Affinity DataKi:  304nMAssay Description:Binding affinity D3 [3H]-PD 128907 receptor was determined using caudate-putamen of adult male Spragueo?=Dawley ratsMore data for this Ligand-Target Pair
TargetD(3) dopamine receptor(Rattus norvegicus (Rat))
University of Michigan

Curated by ChEMBL
LigandPNGBDBM50133928(1-(4-Fluoro-phenyl)-4-(1,2,4,4a,5,6-hexahydro-pyra...)
Show SMILES Fc1ccc(cc1)C(=O)CCCN1CCN2C(CCc3ccccc23)C1
Show InChI InChI=1S/C22H25FN2O/c23-19-10-7-18(8-11-19)22(26)6-3-13-24-14-15-25-20(16-24)12-9-17-4-1-2-5-21(17)25/h1-2,4-5,7-8,10-11,20H,3,6,9,12-16H2
Affinity DataKi:  304nMAssay Description:Inhibition of [3H]-PD 128907 binding to Dopamine receptor D3 in rat ventral striatumMore data for this Ligand-Target Pair
TargetD(1B) dopamine receptor(RAT)
University of Michigan

Curated by ChEMBL
LigandPNGBDBM50133928(1-(4-Fluoro-phenyl)-4-(1,2,4,4a,5,6-hexahydro-pyra...)
Show SMILES Fc1ccc(cc1)C(=O)CCCN1CCN2C(CCc3ccccc23)C1
Show InChI InChI=1S/C22H25FN2O/c23-19-10-7-18(8-11-19)22(26)6-3-13-24-14-15-25-20(16-24)12-9-17-4-1-2-5-21(17)25/h1-2,4-5,7-8,10-11,20H,3,6,9,12-16H2
Affinity DataKi:  904nMAssay Description:Inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1-like in rat brainMore data for this Ligand-Target Pair