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BDBM50134131 (3aR,10S)-2-Benzyl-10-(4-methoxy-phenyl)-1,2,3a,4,9,10-hexahydro-2,9,10a-triaza-cyclopenta[b]fluoren-3-one::CHEMBL342876

SMILES: COc1ccc(cc1)[C@@H]1N2CN(Cc3ccccc3)C(=O)[C@H]2Cc2c1[nH]c1ccccc21

InChI Key: InChIKey=AEIPBGWCBLFAEY-RSXGOPAZSA-N

Data: 1 IC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50134131   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Phosphodiesterase 5A


(Bos taurus)
BDBM50134131
PNG
((3aR,10S)-2-Benzyl-10-(4-methoxy-phenyl)-1,2,3a,4,...)
Show SMILES COc1ccc(cc1)[C@@H]1N2CN(Cc3ccccc3)C(=O)[C@H]2Cc2c1[nH]c1ccccc21
Show InChI InChI=1S/C27H25N3O2/c1-32-20-13-11-19(12-14-20)26-25-22(21-9-5-6-10-23(21)28-25)15-24-27(31)29(17-30(24)26)16-18-7-3-2-4-8-18/h2-14,24,26,28H,15-17H2,1H3/t24-,26+/m1/s1
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MMDB

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Similars

Article
PubMed
n/an/a 60n/an/an/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against bovine phosphodiesterase 5


J Med Chem 46: 4533-42 (2003)


Article DOI: 10.1021/jm0300577
BindingDB Entry DOI: 10.7270/Q2N015X2
More data for this
Ligand-Target Pair