BDBM50135483 1-(6-Methoxy-2-thiophen-2-yl-quinazolin-4-ylamino)-3-methyl-pyrrole-2,5-dione::1-(6-methoxy-2-(thiophen-2-yl)quinazolin-4-ylamino)-3-methyl-1H-pyrrole-2,5-dione::CHEMBL337665

SMILES COc1ccc2nc(nc(NN3C(=O)C=C(C)C3=O)c2c1)-c1cccs1

InChI Key InChIKey=WAPBQFRODQBNJI-UHFFFAOYSA-N

Data  1 IC50  2 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50135483   

TargetTranscription factor Jun(Homo sapiens (Human))
University Of Texas Medical Branch

Curated by ChEMBL
LigandPNGBDBM50135483(1-(6-Methoxy-2-thiophen-2-yl-quinazolin-4-ylamino)...)
Affinity DataIC50:  3nMAssay Description:Inhibition of AP-1-mediated transcriptional activation in human Jurkat cells by luciferase reporter gene assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTranscription factor p65(Homo sapiens (Human))
Columbia University

Curated by ChEMBL
LigandPNGBDBM50135483(1-(6-Methoxy-2-thiophen-2-yl-quinazolin-4-ylamino)...)
Affinity DataEC50:  9.80E+3nMAssay Description:Induction of NFkappaB p65 nuclear translocation in HUVEC cells by immunostainingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTranscription factor p65(Homo sapiens (Human))
Columbia University

Curated by ChEMBL
LigandPNGBDBM50135483(1-(6-Methoxy-2-thiophen-2-yl-quinazolin-4-ylamino)...)
Affinity DataEC50:  4.20E+4nMAssay Description:Potentiation of TNFalpha-induced NFkappaB p65 nuclear translocation in HUVEC cells by immunostainingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed