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BDBM501361 US11021511, Compound 5

SMILES: Nc1nc2n(cnc2c(=O)[nH]1)C1OC2COP(O)(=O)OC3C(COP(O)(=O)OC1C2CO)OC(C3F)n1cnc2c(N)ncnc12

InChI Key:

Data: 2 IC50 1 Kd 1 EC50

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 501361
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
Stimulator of interferon genes protein (aa 139-379 H232R) (Homo sapiens (Human))	BDBM501361 (US11021511, Compound 5) Show SMILES Show InChI	PDB MMDB GoogleScholar	PC cid PC sid UniChem	US Patent	n/a	n/a	<10	n/a	n/a	n/a	n/a	n/a	n/a
Janssen Biotech, Inc. US Patent					Assay Description The human STING SPA binding assay measures displacement of tritium labeled 2′,3′cGAMP (cyclic (guanosine-(2′→5′)-monoph...				US Patent US11021511 (2021)
Janssen Biotech, Inc. US Patent					More data for this Ligand-Target Pair
Stimulator of interferon genes protein (aa 138-378) (Mus musculus (Mouse))	BDBM501361 (US11021511, Compound 5) Show SMILES Show InChI	MMDB GoogleScholar	PC cid PC sid UniChem	US Patent	n/a	n/a	16	n/a	n/a	n/a	n/a	n/a	n/a
Janssen Biotech, Inc. US Patent					Assay Description The human STING SPA binding assay measures displacement of tritium labeled 2′,3′cGAMP (cyclic (guanosine-(2′→5′)-monoph...				US Patent US11021511 (2021)
Janssen Biotech, Inc. US Patent					More data for this Ligand-Target Pair
Stimulator of interferon genes protein (aa 139-379 H232R) (Homo sapiens (Human))	BDBM501361 (US11021511, Compound 5) Show SMILES Show InChI	PDB MMDB GoogleScholar	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	<10	n/a	n/a	n/a	n/a	n/a
Janssen Biotech, Inc. US Patent					Assay Description Compounds were analyzed on an S200 biacore SPR instrument (GE Healthcare). E. coli produced truncated STING protein was immobilized on a series S str...				US Patent US11021511 (2021)
Janssen Biotech, Inc. US Patent					More data for this Ligand-Target Pair
Stimulator of interferon genes protein (aa 139-379 H232R) (Homo sapiens (Human))	BDBM501361 (US11021511, Compound 5) Show SMILES Show InChI	PDB MMDB GoogleScholar	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	210	n/a	n/a	n/a	n/a
Janssen Biotech, Inc. US Patent					Assay Description Agonism of the human STING pathway is assessed in THP1-ISG cells (Invivogen, cat #thp-isg) derived from human THP1 monocyte cell line by stable integ...				US Patent US11021511 (2021)
Janssen Biotech, Inc. US Patent					More data for this Ligand-Target Pair