BDBM501362 US11021511, Compound 6a

SMILES: CO[C@@H]1[C@H]2CO[P@](S)(=O)O[C@@H]3[C@@H](CO[P@@](S)(=O)O[C@H]1[C@@H](O2)n1cnc2c1nc(N)[nH]c2=O)O[C@H]([C@@H]3F)n1cnc2c(N)ncnc12

InChI Key:

Data: 1 IC50  1 Kd  1 EC50

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 501362   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Stimulator of interferon genes protein (aa 139-379 H232R) (Homo sapiens (Human))	BDBM501362 (US11021511, Compound 6a) Show SMILES CO[C@@H]1[C@H]2CO[P@](S)(=O)O[C@@H]3[C@@H](CO[P@@](S)(=O)O[C@H]1[C@@H](O2)n1cnc2c1nc(N)[nH]c2=O)O[C@H]([C@@H]3F)n1cnc2c(N)ncnc12 Show InChI	PDB MMDB GoogleScholar	PC cid PC sid UniChem	US Patent	n/a	n/a	<10	n/a	n/a	n/a	n/a	n/a	n/a
Janssen Biotech, Inc. US Patent					Assay Description The human STING SPA binding assay measures displacement of tritium labeled 2′,3′cGAMP (cyclic (guanosine-(2′→5′)-monoph...				US Patent US11021511 (2021)
					More data for this Ligand-Target Pair
Stimulator of interferon genes protein (aa 139-379 H232R) (Homo sapiens (Human))	BDBM501362 (US11021511, Compound 6a) Show SMILES CO[C@@H]1[C@H]2CO[P@](S)(=O)O[C@@H]3[C@@H](CO[P@@](S)(=O)O[C@H]1[C@@H](O2)n1cnc2c1nc(N)[nH]c2=O)O[C@H]([C@@H]3F)n1cnc2c(N)ncnc12 Show InChI	PDB MMDB GoogleScholar	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	6	n/a	n/a	n/a	n/a	n/a
Janssen Biotech, Inc. US Patent					Assay Description Compounds were analyzed on an S200 biacore SPR instrument (GE Healthcare). E. coli produced truncated STING protein was immobilized on a series S str...				US Patent US11021511 (2021)
					More data for this Ligand-Target Pair
Stimulator of interferon genes protein (aa 139-379 H232R) (Homo sapiens (Human))	BDBM501362 (US11021511, Compound 6a) Show SMILES CO[C@@H]1[C@H]2CO[P@](S)(=O)O[C@@H]3[C@@H](CO[P@@](S)(=O)O[C@H]1[C@@H](O2)n1cnc2c1nc(N)[nH]c2=O)O[C@H]([C@@H]3F)n1cnc2c(N)ncnc12 Show InChI	PDB MMDB GoogleScholar	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	53	n/a	n/a	n/a	n/a
Janssen Biotech, Inc. US Patent					Assay Description Agonism of the human STING pathway is assessed in THP1-ISG cells (Invivogen, cat #thp-isg) derived from human THP1 monocyte cell line by stable integ...				US Patent US11021511 (2021)
					More data for this Ligand-Target Pair